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Abstract : To determine whether or not a naturally occurring antioxidant, known as GSE, can prevent the bleached enamel surface from being discolored when exposed to a staining solution (tea). And also to compare the color change improvement potential of 10% GSE on home (35% carbamide peroxide) and in-office (40% hydrogen peroxide) bleach after staining. A total of 64 freshly extracted intact human premolars were collected for the experimental groups. The sample were divided into two mains groups in office (hydrogen peroxide 40%) and in home (carbamide peroxide 35%) each main group contain 32 tooth sample subdivided into 16 teeth immersed in artificial saliva and 16 teeth treated with grape seed extract (GSE) then each subgroup divided into 8 teeth immersed in distilled water and 8 teeth immersed in tea as staining solution. Results showed that there was a significant difference in color stability between the office and home bleaching in each antioxidant and media except in artificial saliva there is no significant difference when the storage media is tea, this indicated that bleaching is enhanced by the application of antioxidants (GSE) even after discoloration with tea.

Abstract : Child and adolescent mental health is a pertinent issue that would benefit from creative and gamified new approaches. Circus skills and mindfulness methods are transdiagnostic interventions that have additive effects in synergy. This article focuses on the pilot testing and preliminary efficacy analysis of a novel circus-based mindfulness intervention. 50 participants were randomized into intervention and control groups. Intervention groups received a combined circus and mindfulness intervention; control groups only received a mindfulness intervention of comparable duration. Multiple analysis MANOVA was employed to identify differences between intervention and control groups on measures of depression, anxiety, stress, mindfulness, psychological flexibility, and fear of Covid-19. Upon Wilcoxon signed rank tests, there were significant differences for the pre- and post-intervention scores for fear of Covid-19 and psychological flexibility. There was no significant difference in the intervention group for depression, anxiety, stress and mindfulness. Upon multiple analysis MANOVA, there was a significant difference between the scores for fear of Covid-19 between the control and the intervention group. There was no significant difference between the control and intervention group for depression, anxiety, stress, mindfulness and psychological flexibility. In conclusion, it is observed that psychological flexibility and fear of Covid-19 are two construct that have the potential to be influenced by interventions combining circus and mindfulness interventions. Further larger-scale research is essential in replicating these pilot findings.

Abstract : Digital health has become an increasingly salient point in today’s ever-changing healthcare landscape. At the same time, the Internet is democratising information related to healthcare, as a quick search about simple healthcare conditions will yield hundreds of thousands of healthcare-related search results. UMS University Hospital (HUMS) was established and is poised to become the first Smart Hospital in the State of Sabah. As part of the overall branding and implementation of HUMS as a smart hospital, an app was conceptualized called OHIDAS (“health” or “wellness” in the local Kadazan language). OHIDAS is a mobile application that will serve two major objectives namely promoting healthy lifestyle practices among the community and advocating for health screening prior to illness to maintain health and well-being in our communities and prevent illness caused through NCDs. There are four stages of OHIDAS; health promotion and primary prevention, telemedicine, capturing of patients’ bioinformatics, and full integration of clinical care with mobile application. OHIDAS has been integrated with the Portable Health Clinic of Kyushu University and a proprietary telemedicine system established by HUMS, which were both developed and expedited in view of the Covid-19 pandemic. In conclusion, OHIDAS will help to reinforce HUMS’s corporate identity through HUMS’s core values of “compassionate” and “empowering”. OHIDAS has the potential to become a highly effective tool for health promotion and primary prevention.

Abstract : Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Andrographis paniculata (AGP) was anti-inflammatory by inhibiting nuclear factor-kappa B (NF-κB), a family of transcription factors that plays a central role in the inducible nitric oxide synthase (iNOS) expression. To prove the effect of AGP on NF-κB p65 and iNOS expression in lipopolysaccharide-induced liver injury in a rat model of sepsis. Immunohistochemistry (IHC) was performed on 30 liver paraffin blocks from 5 groups of male Wistar rats: K1: healthy control; K2: negative control; P1, P2, and P: rats had given AGP doses of 200, 400, and 500 mg/kg BW/day for 14 days. The mean NF-κB p65 and iNOS expression scores in the K1: 3.83±0.408 and 2.83±0.753; K2: 4.00±0.000 and 3.67±0.516; P1: 3.50±0.837 and 3.50±0.837; P2: 3.83±0.408 and 3.83±0.408; P3: 3.83±0.408 and 3.67±0.516. AGP doses of 200, 400, and 500 mg/kg BW/day did not affect NF-κB p65 and iNOS expression in lipopolysaccharide-induced liver injury in a rat model of sepsis. The NF-κB p65 and iNOS expression had a significant correlation (p<0.05) with a coefficient value of 0.514 (moderate). AGP extract prevents the accumulation of lipids that lead to liver necrosis. NF-κB p65 expression had a significant correlation with iNOS expression (p<0.05).

Abstract : Alpha thalassemia is a genetic disorder of hemoglobin synthesis deletion or non-deletion mutation of the alpha-globin gene. Non-deletional mutations cause abnormalities in the structure of alpha-globin chain, creating an unstable variant of hemoglobin. Furthermore, hemoglobin Adana (HbAdana) and Constant Spring (HbCS) are common non-deletional alpha-thalassemia in Indonesia. However, compound heterozygosity cases of these types of mutations have rarely been reported. A 12-year-old boy is hospitalized with anemia, and complete blood count showed hemoglobin 9.1 g/dL, Mean Corpuscular Volume (MCV) 87.2 fl, and Mean Corpuscular Hemoglobin (MCH) 24.3 pg. On microcapillary hemoglobin electrophoresis examination, HbA 95.7%, HbA2 1.5%, and HbC 2.8% were obtained, and they led to the suspicion of HbCS. Furthermore, examination of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) found compound heterozygosity of HbAdana and HbCS. The genetic inheritance of compound heterozygosity Hb Adana and HbCS was discovered as the father was heterozygous for HbCS and the mother was heterozygous for Hb Adana. Generally, non-deletional mutations produce variant hemoglobin that is not clinically significant. However, when the point mutation occurs in essential amino acid residues, it will result in very unstable hemoglobin, which causes more serious clinical symptoms of hemolytic anemia than the deletional mutation. HbAdana and HbCS are variants of alpha thalassemia that are very unstable and can easily prevent hemolysis. Therefore, the compound heterozygosity of the two non-deletional mutations causes recurrent severe anemia. The compound heterozygosity of non-deletional alpha-thalassemia mutation is very rare, and microcapillary hemoglobin electrophoresis with molecular examinations are required for the diagnosis of HbAdana and HbCS.