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Abstract : To compare two new correction methods for SNA and SNB to a classical method, their impact on SNA and SNB measurements and their correlation to clinical examination, using lateral cephalograms taken in the natural head position guided by the K plane. The Orienter was used to orient the head in the natural head position during lateral cephalograms and clinical examination. Frankfurt Horizontal, SNA, SNB and the orientation angle were measured for 24 adults with age range of 18-24 years. According to the three methods investigated, compensations in SNA and SNB angles were made and the skeletal jaw relation was determined in each method. Comparisons between the methods were made and the correlation between the skeletal jaw relation and the clinical skeletal jaw relation was determined. For both SNA and SNB, there was a statistically significant difference between A1 and each of A2 and A3 (p=0.002), and A3 and each of A2 and A4; (p=0.015) and (p=0.001), respectively. The interclass correlation coefficient between A4 skeletal jaw relation and clinical jaw relation was 0.936. The correction of SN/FH, SNA and SNB angles using the orientation angle, provided a better and more realistic diagnosis that closely matched clinical reality.

Abstract : Connective tissue grafts are considered the golden standard for the treatment of gingival recession. Several techniques were previously mentioned in the literature about harvesting connective tissue grafts, but these techniques have many complications. Thus, this study aimed to describe a new harvesting method for to limit those consequences, as well as decreasing pain level, and reducing surgical time. The main objective of this study was to describe a new harvesting method for connective tissue graft using a double-bladed scalpel compared to the conventional scalpel which has been used for harvesting de-epithelialized free gingival graft for the treatment of gingival recession. The study sample comprised of 24 surgical sites in 12 patients, at the Faculty of Dentistry_ Damascus University using a split-mouth design. The control group comprised of 12 surgical sites of bilaminar single gingival recession which were classified as Miller’s class I and managed with a conventional scalpel for harvesting de-epithelialized free gingival graft. The test group also comprised of 12 surgical sites of bilaminar single gingival recession which were classified as Miller’s class I and managed with a double-bladed scalpel for harvesting connective tissue graft. The following clinical indices were evaluated: 1) Gingival thickness 2) Patient esthetic satisfaction 3) Duration of surgery 4) Pain level. The test group showed statistically significant differences regarding patient’s pain level, surgical time, and esthetic satisfaction. Whereas the control group showed statistically significant differences regarding gingival thickness index. This new technique for harvesting connective tissue graft using a double-bladed scalpel has many advantages as we could harvest a uniform graft with a convenient thickness for root coverage procedures, resulting in surgical time reduction, decreasing patient pain level, and increasing patient esthetic satisfaction.

Abstract : Evaluation of oocyte quality is one of the most important goals of embryologists in assisted reproductive technologies, due to its importance in successful fertilization and embryonic development. Females undergoing in vitro fertilization are exposed to massive systemic oxidative stress due to the ovarian stimulation protocols used, which negatively affects oocyte maturation and embryonic development. Glutathione peroxidase is one of the most important endogenous antioxidants purported to defend against oxidative stress by modifying free radical electrons, and therefore it is necessary to investigate the effect of its blood levels on oocyte maturation and the embryo quality in women undergoing in vitro fertilization treatment. An observational, cross-sectional study was conducted on 60 females undergoing IVF treatment by pituitary down-regulation with GnRH agonist. Glutathione peroxidase-1 levels in serum and follicular fluid were determined using an ELISA kit. The maturity of the oocyte nucleus as well as the development of the resulting embryos after sperm injection are evaluated by IVF specialists. Grade Ι embryos resulting from the injection of high-quality oocytes are what the doctor seeks to obtain to return these embryos to the uterus. We investigated the relationship between serum glutathione peroxidase levels with the number and quality of MΠ oocytes and Grade Ι embryos using Statistical Package for Social Sciences version 23. We found that the relationship between GPX activity in the blood (measured in µU/ml) and the number of mature oocytes (MΠ), maturation rate, fertilization rate, and the number of Grade Ι embryos were found to be statistically non-significant, with a p-value of 0.709, 0.327,0.720, 0.385, respectively. The GPX activity measured in the blood was not associated with any IVF/ICSI indicators. This suggests that further comprehensive research is needed in this area.

Abstract : Alcohol poisoning is a community occurrence stemming from sources such as ethylene glycol, methanol, or long-term use of ethanol. One preferred therapy for this situation is fomepizole, an alcohol dehydrogenase (ADH) inhibitors with a relatively high price. Therefore, this study aimed to identify ADH inhibitors candidates among compounds sourced from the Combretum genus. The method used leverages the KNApSAcK database for screening and integrates Pharmit, swissADME, admetSAR, autodock4, and molecular dynamics. The results yielded 5 compounds from Pharmit to Autodock, with an additional 3 through molecular dynamics. These determinations were made based on various parameters such as SASA, RMSD, RMSF, Rg, Hydrogen bond, and Binding energy, all of which assess the stability and bond strength of the enzyme ligand complex. In conclusion, this investigation has identified 3 promising compounds with ADH inhibitory potential, namely 6,7-dihydroxy-2,3,4-trimethoxyphenanthrene; Isobathacin I, and ellagic acid.

Abstract : Several studies were conducted on materials that help bone defects to heal, as they were compared to find out the best material in terms of speed, quality, bone formation, absorption following the grafting, and economic cost, The aim of this research is to study the effect of a new material, Bone Morphogenetic Proteins (BMP) carried on a gelatinous foam scaffold in comparison with the Xenograft BioOss® in the management of bone defects made in rabbit thighs radial and histological. The sample included 10 male rabbits at the age of one year. Each rabbit had 4 identical cylindrical holes with a diameter of 5 mm and a length of 5 mm within the femur, so that each hole belongs to a group. It was placed within the holes of the first group BMP2 with a gelatin sponge, and the defects of the second group were left empty. A gelatin sponge was placed alone within the holes of the third group, and the BioOss® graft was placed within the defects of the last group. The radiographic evaluation was conducted after one month and two months after the surgical work, and the histological assessment was conducted two months after the surgical work. A ONE-WAY ANOVA test was conducted, and it was found that there was a difference between the four groups, and when comparing each two groups separately using the TUKEY test, it was found that healing in the holes in which BMP2 was placed was better than healing in the holes in which the gelatin sponge was placed and also those that were left for spontaneous healing, but There was no significant difference between it and the healing in the holes filled with BioOss®. The use of a gelatin sponge impregnated with Bone Morphogenetic Proteins improves and accelerates the healing of bone defects and is comparable to the effectiveness of using a BioOss® graft.