Abstract : Alcohol poisoning is a community occurrence stemming from sources such as ethylene glycol, methanol, or long-term use of ethanol. One preferred therapy for this situation is fomepizole, an alcohol dehydrogenase (ADH) inhibitors with a relatively high price. Therefore, this study aimed to identify ADH inhibitors candidates among compounds sourced from the Combretum genus. The method used leverages the KNApSAcK database for screening and integrates Pharmit, swissADME, admetSAR, autodock4, and molecular dynamics. The results yielded 5 compounds from Pharmit to Autodock, with an additional 3 through molecular dynamics. These determinations were made based on various parameters such as SASA, RMSD, RMSF, Rg, Hydrogen bond, and Binding energy, all of which assess the stability and bond strength of the enzyme ligand complex. In conclusion, this investigation has identified 3 promising compounds with ADH inhibitory potential, namely 6,7-dihydroxy-2,3,4-trimethoxyphenanthrene; Isobathacin I, and ellagic acid.