Search Results

Abstract : Antibiotic resistance is increasingly emerging and represented as a top healthcare challenge that necessitates seeking alternative antibiotic remedies including herbal resources. Tea widely used beverage and different effective actions have been documented for tea extracts, such as antioxidant, antibacterial, and anticancer effects. We aimed to compare the antibacterial action of green versus red tea extracts. To do so, a model was created by exposing rats to E Coli infecting their kidneys and then using green and red tea extract to tackle the infection, if any. The results of the study were documented through histopathological analysis of rat's kidney alongside measuring serum creatinine and urea of studied group using control negative and control positive group for comparisons. Additional ciprofloxacin was used, as a prototype antibiotic effective against urinary tract infection, for comparison with red and green tea extracts. Green tea extracts were found to have an effective role in reducing lesions green tea was superior to red tea and was similar to ciprofloxacin in decreasing the pathological effects of E. coli bacteria on rat kidney tissue.

Abstract : Recently, therapeutic plants are widely being used to manage, prevent, and treat multiple diseases. Pomegranate are broadly known for their antioxidant, anti-cancer and anti-inflammatory effects. It is rich in compounds like maslinic acid, gallic acid, ethyl brevifolin-carboxylate, ellagic acid etc. Furthermore, the peel of pomegranate is composed of a large number of phytochemicals (biologically active compounds) like flavonoids, phenolic acids, and tannins contributing to its antimicrobial and antifungal properties. Through this study we aim to examine the exact phytochemicals and screen the total crude hydroalcoholic extract and flavonoids against gram negative and gram positive bacteria through MIC test and agar disc diffusion method. The results using disc diffusion method demonstrated that the least inhibition zone was of E. coli while the maximum zone of inhibition was of Staphylococcus aureus and in case of Pseudomonas aeruginosa it has a less antibacterial action. The inhibition reactions differ amongst pomegranate flower compounds as well, like flavonoid was more effective than crude in inhibiting microorganisms. pomegranate flower extracts displayed significant antimicrobial and antioxidant effects.

Abstract : Psoriasis is an autoimmune disease characterized by the proliferation of keratinocytes throughout time. On average, it affects 2-5 % of the world's population. Psoriasis treatment remains difficult due to a variety of factors influencing treatment, including patient compliance and therapy adherence, profiles of delicate patients, psychological factors, and topical delivery skin work as a barrier. Topical therapy is the most common treatment choice, and it has few side effects. Biological therapy has improved the efficacy of traditional psoriasis treatment and enhanced patient acceptance due to fewer side effects. Nano formulations have an advantage over traditional therapy since they have a better anti-psoriatic effect and fewer adverse effects. Psoriasis symptoms can be reduced with phytopharmaceuticals as a supplemental and alternative therapy. In the present review, we are summarizing the most important types of psoriasis therapy.

Abstract : Escherichia coli and Klebsiella pneumonia are common human pathogens that are responsible for causing a wide range of human infections, including urinary tract infections and many sexually transmitted diseases, which are raising a severe threat to public health and quality of life. Recently, many naturally occurring substances, including plants, have been interested in the production of therapeutic drugs. Pomegranate plants are proven to have considerable antibiotic and antimicrobial effects. The following study aims to investigate the impact of pomegranate extracts and their antimicrobial effects on Klebsiella pneumonia and Escherichia coli bacteria. The sensitivity of the tablets was examined on the Mueller Hinton agar medium of the microbe's understudy with a concentration of 10 continuous formation units/ml. The results indicated that the extracts of the pomegranate plants were more effective on E.coli as compared to Klebsiella pneumonia. However, the effectiveness and the antimicrobial effects of the extracts were evidently observed in both cases. Furthermore, there is a requirement to investigate the adverse effects and associated impacts of pomegranate extracts.

Abstract : Deficiency of vitamin D is linked to reduced insulin secretion and increasingly reported in type 2 diabetes mellitus in epidemiological as well as experimental studies. A trial of animals demonstrates that 1,25 dihydroxy vitamin D regulates the β cell of the pancreas for secretion of insulin. A connection between resistance of insulin and deficiency of vitamin D is influenced by presence of inflammatory marker is linked with vitamin D deficiency. Vitamin D genetic mutation may predispose to type 2 diabetes and glycemic control. Epidemiological studies demonstrated a link between 24-hydroxyvitamin D3 low-level serum amount and increased risk of type 2 diabetes and metabolic syndrome, which an increase in fat mass may partially describe. A possible normal relationship linking with type 2 diabetes and vitamin D deficiency should be verified by a randomized clinical trial demonstrating that either vitamin D supplements may improve insulin resistance and insulin sensitivity or prevent type 2 diabetes. The result of randomized controlled trials (RCT) on an impact of placebo versus Vitamin D, occasionally combination with calcium and prediabetes. Review of available studies demonstrated decreased in glucose fasting plasma or improved insulin resistance. Meta-analysis of RCT does not show a significant effect on glycemic control by vitamin supplementation. Nowadays, a large RCT is performed for a high dose of vitamin D to control glycemic control. The deficiency of vitamin D needs to be regulated or prevented; until then, no vitamin D supplementation should be recommended to avoid type 2 diabetes.