Abstract : Recently, therapeutic plants are widely being used to manage, prevent, and treat multiple diseases. Pomegranate are broadly known for their antioxidant, anti-cancer and anti-inflammatory effects. It is rich in compounds like maslinic acid, gallic acid, ethyl brevifolin-carboxylate, ellagic acid etc. Furthermore, the peel of pomegranate is composed of a large number of phytochemicals (biologically active compounds) like flavonoids, phenolic acids, and tannins contributing to its antimicrobial and antifungal properties. Through this study we aim to examine the exact phytochemicals and screen the total crude hydroalcoholic extract and flavonoids against gram negative and gram positive bacteria through MIC test and agar disc diffusion method. The results using disc diffusion method demonstrated that the least inhibition zone was of E. coli while the maximum zone of inhibition was of Staphylococcus aureus and in case of Pseudomonas aeruginosa it has a less antibacterial action. The inhibition reactions differ amongst pomegranate flower compounds as well, like flavonoid was more effective than crude in inhibiting microorganisms. pomegranate flower extracts displayed significant antimicrobial and antioxidant effects.