Escherichia coli and Klebsiella pneumonia are common human pathogens that are responsible for causing a wide range of human infections, including urinary tract infections and many sexually transmitted diseases, which are raising a severe threat to public health and quality of life. Recently, many naturally occurring substances, including plants, have been interested in the production of therapeutic drugs. Pomegranate plants are proven to have considerable antibiotic and antimicrobial effects. The following study aims to investigate the impact of pomegranate extracts and their antimicrobial effects on Klebsiella pneumonia and Escherichia coli bacteria. The sensitivity of the tablets was examined on the Mueller Hinton agar medium of the microbe's understudy with a concentration of 10 continuous formation units/ml. The results indicated that the extracts of the pomegranate plants were more effective on E.coli as compared to Klebsiella pneumonia. However, the effectiveness and the antimicrobial effects of the extracts were evidently observed in both cases. Furthermore, there is a requirement to investigate the adverse effects and associated impacts of pomegranate extracts.