Abstract : Antibiotic resistance is increasingly emerging and represented as a top healthcare challenge that necessitates seeking alternative antibiotic remedies including herbal resources. Tea widely used beverage and different effective actions have been documented for tea extracts, such as antioxidant, antibacterial, and anticancer effects. We aimed to compare the antibacterial action of green versus red tea extracts. To do so, a model was created by exposing rats to E Coli infecting their kidneys and then using green and red tea extract to tackle the infection, if any. The results of the study were documented through histopathological analysis of rat's kidney alongside measuring serum creatinine and urea of studied group using control negative and control positive group for comparisons. Additional ciprofloxacin was used, as a prototype antibiotic effective against urinary tract infection, for comparison with red and green tea extracts. Green tea extracts were found to have an effective role in reducing lesions green tea was superior to red tea and was similar to ciprofloxacin in decreasing the pathological effects of E. coli bacteria on rat kidney tissue.