Search Results

Abstract : Diffuse large B cell lymphoma (DLBCL) is the most common type of malignant lymphoma. EBV status have been used as prognostic markers to predict prognosis and determine therapeutic strategies with some controversial evidences on both DLBCL subtypes. Our study was the first study in Indonesia aimed to evaluate differences of EBV status between both DLBCL subtypes as well as to assess the immunophenotype profile. We selected 40 DLBCL cases (20 GCB and 20 Non-GCB subtypes). The classification for each subtype was determined using Hans Criteria. EBV status was evaluated by two independent observers with a cut-off point of 20% to define EBV positivity. Kappa analysis was used to reduce bias. EBV-positive was found in 4/40 (10%) cases and most were patients with non-GCB subtypes. Our results showed a satisfactory agreement between the two observers (kappa 0,952). We found that EBV-positive was more common among non-GCB subtypes.

Abstract : The coexistence of anemia and stunting (CAS) is a double burden of malnutrition that can result in the intergenerational cycle of malnutrition. Among adolescent girls, it will bring negative consequences on growth, school performance, morbidity, and reproductive performance. We aimed to assess the prevalence and determinants associated factors with CAS among adolescent girls aged 13-15 years in a coastal area of Indonesia. We conducted a cross-sectional study of 247 adolescent girls in junior high schools selected with a proportional random sampling technique. We collected data using a valid and standardized questionnaire. The hemoglobin level and anthropometric measures of participants were taken according to the World Health Organization standards. Dietary practice data was collected using a semi-quantitative food-frequency questionnaire. Associations between determinant variables with CAS were analyzed using bivariate (chi-square test) and multivariate (multilevel logistic regression test). The overall prevalence of CAS was 5.7%. The bivariate analysis results revealed determinants that were significantly related to CAS were energy intake, protein, zinc, maternal education, and maternal occupation. Furthermore, the multivariate analysis results showed protein intake (OR=0.793, 95%CI=0.690-0.912, P=0.001), zinc intake (OR=3.356, 95%CI=1.183-9.520, P=0.023), and maternal occupation (OR=8.663, 95%CI=1.162-64.564, P=0.035) were determinants that significantly contributed to CAS among adolescent girls in a coastal area of Indonesia. We concluded that inadequate dietary and low socio-economic status were the main predictors of CAS among adolescent girls in a coastal area of Indonesia. We recommended that the improvement of the quality of food consumption and intensive parental health education are required.

Abstract : The literature on risk factors of osteoporosis in Saudi women is scarce and has several methodological limitations. This study aimed to assess the risk factors of osteoporosis among Saudi women in Qassim region of Saudi Arabia. An institution-based case-control study was conducted among women diagnosis of osteoporosis based on DEXA scan. Cases were recruited from regional DEXA scanning center of Qassim while controls were women visiting primary health care center. Data was collected using a structured questionnaire which collected information on socio-demographic and menopause and medical history. Analysis was done on SPSS version 23.0. Logistic regression was used to assess the risk factors and crude and adjusted odds ratio along with their associated 95% confidence intervals (CI) were calculated. A total of 115 cases and 183 controls were included in the analyses. The mean age of cases was higher than controls 64 ± 8.0 years versus 56.6 ± 7.6 years respectively. In the multivariate analysis, BMI adjusted OR 0.88 (95% CI: 0.82 – 0.94), menopause adjusted OR 13.33 (95% CI: 1.56 – 113.5), History of fragility fracture adjusted OR 0.07 (95% CI: 0.015 – 0.37) and hypothyroidism adjusted OR 0.31 (95% CI: 0.13 – 0.78) were significantly associated with osteoporosis. BMI, menopause, history of fragility fracture and hypothyroidism were significantly associated with osteoporosis in this study population. Studies with larger sample size and focused exposure should be carried out to draw conclusive relationship with osteoporosis.

Abstract : Obesity can cause respiratory disorders caused by the accumulation of adipose tissue and numerous cytokines produced by adipocytes. Tobacco smoking, on the other hand, is primarily associated with the occurrence of a wide range of lung diseases characterized by diffuse changes in lung tissue and a decrease in the respiratory volume of the lungs. This research was conducted to study the features of ultrastructural changes in the lungs of sexually mature male rats under conditions of experimental obesity and tobacco smoking to study the pathological changes in lung tissue both under the conditions of isolated exposure to obesity and tobacco smoking and in the case of their combined influence under experimental conditions. The total sample of experimental animals included 120 rats divided into four groups randomly: the control group (n=30) – conditionally healthy rats, animals were fed according to a standard diet; a group of rats exposed to isolated tobacco smoke influence (n=30); a group of rats with experimental obesity (n=30), and a group of rats with experimental obesity simultaneously exposed to tobacco smoking (n=30) – feeding using a high-fat diet with exposure in a chamber with tobacco smoke. The identified ultrastructural features of the lungs in the group of rats with experimental obesity and the group of rats with experimental obesity simultaneously exposed to tobacco smoking did not differ qualitatively, which suggests that the pathological changes in the lungs tissue ultrastructure developed regardless of the presence or absence of a direct damaging effect of passive smoking on the lung tissue.

Abstract : Self-injury is an activity that is concealed by the person who engages in it. According to previous research, 32.1% of nursing students had self-injury behavior. Self-injury behavior is directly related to suicidal ideation. Personality factors can assist in the selection of interventions to treat self-injury behavior, so it becomes important to examine the relationship between personality and self-injury. This study aims to identify the relationship between personality factors, specifically the Big Five Personality, and self-injury behavior. The research design used a descriptive correlational design. The population of this study was undergraduate students in the Faculty of Nursing, with a sample of 438 students. The instruments used are the Big Five Inventory (BFI) and the Deliberate Self-Harm Inventory (DSHI). The data was analyzed using descriptive statistical methods and the Rank Spearman. The results showed that there was a positive significant relationship between neuroticism and self-injury behavior, while between agreeableness and conscientiousness and self-injury behavior there was a negative significant relationship. The higher an extraversion score, the greater the risk of self-injury; however, the higher agreeableness and conscientiousness scores, the lower the risk of self-injury.