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Abstract : Salacialehmbachii has been used in traditional medicine to treat malaria and anaemia, convulsion, pains, inflammation, respiratory disorders, and other health challenges. This study evaluated the antiplasmodial activity and hematological parameters in Plasmodium berghei-infected mice treated with ethanol root extract of S.lehmbachii. Sixty healthy Swiss mice were used for this study. The 4-day suppressivetest, curative effects against established rodent malaria infection in mice models and haematological indices. The animals were treated with 20 mL/kg of distilled water, chloroquine 10 mg/kg, 50 mg/kg, 100 mg/kg and 200 mg/g of the ethanol root extract, respectively. The extract at varying doses, significantly (p<0.05 and p<0.01) exhibited a dose-dependent decrease in parasitemia in suppressive and curative studies. Chloroquineat 10 mg/kg significantly (p<0.01) decreased parasitemia levels in the two models of malaria infections. The effect elicited by the extract against plasmodium is equivalent to standard drug in terms comparison. There was a significant increase (p<0.01) in hematological indices. However, there was also a decrease (P <0.05) in WBC and its differentials. The secondary metabolites revealed potential phytoconstituents. The extract was found to be non-toxic in mice at 5000 mg/kg. The findings show that S. Lehmbachiiethanol root extract demonstrated high antiplasmodial activity in a dose-dependent fashion and improved hematological indicesin plasmodia infected mice.

Abstract : Musculoskeletal Disorders (MSDs) are disorders or damage the muscular and skeletal systems of the human body caused by an imbalance of workload on the capabilities of the muscles and skeleton which significantly directly or indirectly reduce work productivity. Workload can be divided into two, which are physical workload and mental workload which tends to lead to the burden received by an employee in a job. This study aimed to analyze the effects of physical workload, mental workload and work posture towards fatigue on Musculoskeletal Disorders in employees at PT. Nusantara Plantation XIV. This type of research was an analytic observational with a cross sectional research design. The sample used the non-probability sampling method with a sample of 118 respondents. The data collection instruments included an oxymeter, reaction speed, Rapid Entire Body Assessment (REBA), Nordic Body Map and NASA-TLX questionnaires, interviews and observations. The data analysis used in this study was the path analysis. There was a direct effect of work posture on fatigue (p=0.000). Physical workload on fatigue (p=0.038). Mental workload on fatigue (p=0.004). Work posture towards MSDs (p=0.533). Physical workload on MSDs (p=0.188). Mental workload on MSDs (p=0.000). There was an indirect effect of work posture on MSDs through fatigue (p=0.020). The work posture and physical workload did not have a direct effect on musculoskeletal disorders, while work posture, physical workload and mental workload had a direct effect on fatigue and musculoskeletal disorders and there was an indirect effect of work posture on musculoskeletal disorders through fatigue.

Abstract : Eclampsia and Pre-eclampsia account for about half of these cases Worldwide and have been recognized and described for year despite the general lack of understanding of the disease. Hypertension is the most common medical problem encountered during pregnancy. Pre-eclampsia (PE) is a metabolic disorder that adversely affects the lives of mother and their infants. Even though, several studies have been conducted on PE, no effective diagnostic and therapeutic agents were developed so far. Eclampsia, which is considered a complication of sever pre-eclampsia. It is commonly defined as new onset of Grand mal seizure activity or/and unexplained coma during pregnancy or postpartum in a female with signs or symptoms of pre-eclampsia Hence, this study was designed to evaluate serum uric acid, blood urea and creatinine levels in the prediction of Pre-eclampsia (PE) and Eclampsia. A hospital-based case-control study was conducted among pregnant women’s. A simple random sampling technique was applied to select study participants. The clinical data were collected. Serum samples were used to determine the maternal uric acid, urea and creatinine levels via an automated chemistry analyzer. Independent sample t-test, Pearson correlation test analysis were performed to check the association and diagnostic accuracy of variables Eclampsia to pre- eclampsia. The mean ages (in years) of the case and control groups were 17 to 20 age group with 11, 12 & 06 patients, 21 to25 age group with 33,11 & 17 patients, and 26 to31 age group with 6, 02 & 03 patients of controls, pre- eclampsia and eclampsia respectively. The above geographical distribution of patients. In pre-eclampsia 21 is rural & 04 is urban and in eclampsia 25 is rural & 01 is urban and no one is found in tribal. The age wise comparison of uric acid, urea and creatinine of cases in pre-eclampsia. The most deviation is shown by age group 26 to 31. The comparison of all parameters in controls and cases of pre-eclampsia. The Uric acid 9.676±3.376, urea 44.544±9.152 and creatinine1.2560±0.3841 are highly significant in cases as compared to control group of Uric Acid 3.3145±0.910 Urea 30.168±8.287 and Creatinine 0.7366±0.1686 comparison of all parameters in control and cases of eclampsia. Uric acid, urea and creatinine are highly significant in cases as compared to control groups respectively. In this study, Uric acid is found to be highly significant in 2nd and 3rd age group (P<0.001) and not significant in 1st and 2nd & 3rd and 1st age group. Urea is found to be highly significant in all compared age group (P<0.001). Creatinine is found to be not significant in any compared age group in Pre -eclampsia patients and Uric acid is found to be not significant in any compared age group. Urea is found to be highly significant in 2nd and 3rd age group (P<0.001) and not significant in 1st and 2nd & 3rd and 1st age group. Creatinine is found to be not significant in any age group of eclampsia Patients. But their inclusion in routine diagnostic test to eclampsia & Pre-eclampsia requires large-scale multi-center prospective studies that corroborate our findings.

Abstract : Nurses' lack of understanding about triage management causes the transmission and spread of COVID-19 infection to health workers and patients because the implementation of triage is not in accordance with the COVID-19 health protocol. This study aims to evaluate the implementation of triage for post-COVID-19 emergency services in the city of Palu, Indonesia. This study used a quantitative research method with a cross-sectional research design, the sample in this study were ER and community nurses who are members of the COVID-19 task force in the Palu City area of 30 participants with a sampling technique using purposive sampling, and respondents were given a measuring instrument containing a questionnaire containing regarding the standard management of triage COVID-19. Furthermore, the data were analyzed using a correlation test. The results showed that the evaluation of the implementation of COVID-19 triage in post-COVID-19 pandemic nursing health workers in Palu City, Indonesia, was in the good category based on the Spearman rho correlation value of 0.683. The implementation of triage in this study was influenced by the experience and tenure of nurses, with a length of service of more than 10 years. Classification and labeling of triage based on clinical signs and symptoms of COVID-19 patients (86.7%) using the Emergency Medical Services system (83.3%) and (40%) of respondents did not know alternative triage areas during the spike in cases of COVID-19. Implementation of COVID-19 triage as a basis for patient management in order to suppress the spread of infection after the COVID-19 pandemic.

Abstract : Dengue Hemorrhagic Fever is a major health problem in Indonesia. The existence of Aedes Aegypti mosquito is the main vector that causes Dengue Hemorrhagic Fever [9]. The bionomics of the Aedes Aegypti mosquito is a risk factor for causing Dengue Hemorrhagic Fever (Mawardi and Busra, 2019). The incidence of Dengue Fever in the people of Enrekang Regency is influenced by the living habits of the Aedes Aegypti mosquito. Bionomic data of the Aedes Aegypti mosquito in the Enrekang Regency area is not yet available. In the Enrekang district, there were 166 cases of dengue fever in 2019, an increase of 209 cases in 2020, and a decrease in 2021 of 64 cases. Cases of Dengue Hemorrhagic Fever in Enrekang district are included among the 10 highest diseases. To determine the bionomic relationship (biting and resting behavior) of Aedes Aegypti mosquitoes with the incidence of Dengue Hemorrhagic Fever in the Enrekang district. The method in this research is analytic observational using a cross-sectional study approach. Analytical observational is research that tries to identify how health phenomena occur. Sampling was done by the total sampling method. The data was obtained directly from the Enrekang District health office. The results showed that there was no significant relationship between the biting behavior of Aedes Aegypti mosquitoes (p = 0.470), while the resting behavior of Aedes Aegypti mosquitoes had a significant relationship (p = 0.000) with the incidence of Dengue Hemorrhagic Fever in Enrekang District. The results of the study show that the habit of the Aedes Aegypti mosquito is a risk factor for Dengue Hemorrhagic Fever in the Enrekang district.