Search Results

Abstract : This study was aimed to determine association between UGT1A1 polymorphism and hyperbilirubinemia among neonates. We conduct searching from PubMed, ProQuest, ScienceDirect, WileyOnline, and Cochrane while applying selection criteria. There were four eligible studies which were good after appraisal using Newcastle-Ottawa scale. Qualitative analysis found there was more UGT1A1 c.3279T>G polymorphism alongside with less expression of UGT1A1 c.189C>T polymorphism in hyperbilirubinemia group. Polymorphism of UGT1A1 c.211G>A and (TA)7 were variative throughout studies, hence quantitative analysis was conducted. There was less c.211G>A GG expression (OR 0.39, 95% CI 0.21–0.71), and more c.211G>A GG GA and c.211G>A GG AA expression with odds ratio of 2.95 (95% CI 1.52–5.70) and 8.06 (95% CI 1.43–45.33) respectively. However, there was insignificant difference noted in UGT1A1 (TA)7 polymorphism and its subtypes (77, 76, 66). Qualitative analysis shown that insignificant difference was also noted in UGT1A1 (TA)7 polymorphism. Therefore, it could be concluded that UGT1A1 polymorphism, especially c.211G>A and (TA)7 was associated with hyperbilirubinemia in neonates.

Abstract : Preceptorship is a learning method that involves more experience in conveying knowledge to someone who is less experienced. In this article, the authors conduct a systematic review of relevant data using the keywords “preceptorship,” “clinical educator,” and experience.” Data based on SCOPUS, Science Direct, Proquest, Pubmed, and Google Scholar. The criteria consist of a full text published in a five-year limit journal (2016-2021) and using articles in English. As a result, 2517 articles were found, and 25 articles were selected that matched the criteria. The purpose of this study is to analyze factors that affect the implementation of preceptorship in the hospital and to give the recommendation of monitoring and evaluation preceptorship as well. Papers were critically reviewed and relevant data were extracted and synthesized using an approach based on preferred reporting items for systematic reviews and Meta-Analysis (PRISMA). These factors include education level, experience, support, clinical education, and competence.

Abstract : Tuberculosis (TB) is an infectious and contagious disease [9]. This disease can be suffered by anyone, but is most often found at a young age or productive age, namely 15-50 years, especially those who are weak, malnourished, or who live in the same house and are jostled with people with pulmonary TB [11]. Family support as the presence of comfort, attention, appreciation or helping people with an attitude of acceptance, family support is obtained from individuals or groups. Family members with pulmonary TB need to get information/guidance, emotional support, feel valued and needed, both family and close people. This support is very necessary so that the patient pays attention to his illness and increases the patient's self-esteem [12]. The purpose of this study was to determine family support, patient awareness with the level of patient visits at the Public Health Center Tuban district. The research design used was correlational analytic with a cross sectional time approach, the population of all patients with pulmonary TB in Tuban district was 270 respondents. The sample in this study were some of the pulmonary TB patients in Tuban district as many as 156 respondents, the independent variables were family support, patient awareness, while the dependent variable was the level of visits. The questionnaire in this study is in the form of a closed-ended question where there are answer choices and respondents just choose the answers that have been provided. Data analysis using spearman rho with SPSS'23 and significant level () 0.05. Most of the respondents received family support in the good category of 68 (43.6%), Most of the respondents had patient awareness in the conscious category of 87 (55.8%), Most of the respondents had a visit rate in the complete come category of 74 (46.8%). Spearman's rho correlation test obtained sig. (2 tailed) = 0.002 meaning that there is a relationship between family support and the level of TB patient visits at the Tuban district health center, the Spearman's rho correlation test obtained sig. (2 tailed) = 0.000 meaning that there is a relationship between patient awareness and the level of TB patient visits at the Tuban district health center. There is a relationship between family support, patient awareness and the level of TB patient visits at the Tuban district health center.

Abstract : Preeclampsia, which is potentially more ominous with adverse pregnancy events that can affect virtually every organ system than other hypertensive disorders. Nitric oxide is one of the most important biologicals signaling molecules that modulate myogenic tone and flow-mediated responses in the resistance vasculature of the uterine circulation and placenta. Nitric oxide is generated by endothelial nitric oxide synthase. To measure the levels of nitric oxide production in patients with pre-eclampsia, and compare these with the levels in women with normal healthy pregnancy without any pre-existing medical problems; and also, to compare these levels between the patients with pre-eclampsia according to it is severity. The study design as a comparative case-control study was performed in Al-Zahraa Teaching Hospital/ Department of Obstetrics and Gynecology in Najaf- city- Iraq, during the period from 15th February till 30th December 2022. In this study, after verbal consent has been taken from all participants, 100 pregnant women, which include (50 cases) of pregnant women which subdivided into (30), complicated by mild pre-eclampsia, (20) complicated by severe pre-eclampsia, and (50 controls) healthy pregnant women, without any pre-existing medical problems. All these pregnant women who have attended to the department of obstetrics and gynecology either for follow-up, or specific reason, or for complication has been developed, during 28 to 40 weeks of pregnancy. Nitric oxide (NO) is a highly unstable biological free radical with a small molecule, which can easily be oxidized to form nitrate (NO-3) and nitrite (NO-2) in the human body and an aqueous solution. The mean serum nitric oxide levels were found in cases groups (Mean±SD 0.021±0.008) in severe preeclampsia, (Mean±SD 0.042±0.009) in mild preeclampsia, and (mean ± SD 0.094 ± 0.009) in control groups, which was significantly (P< 0.040) higher among pregnant women with the control group, while mean serum nitric oxide was significantly lower among pregnant women with severe and mild preeclampsia. There is a partial negative correlation between serum nitric oxide concentration (NO) and means arterial pressure (MAP) (R2 Linear =0.508), a highly significant (p < 0.000), meaning there is a decrease in the concentration of nitric oxide in study groups of severe and mild preeclampsia correlated partial negatively with an increase in mean arterial pressure of these study groups. As the pregnancy progressed there was a decrease in nitric oxide levels in preeclampsia related to it is the severity.

Abstract : Physical abnormalities can be found in Down Syndrome patients. ALX3 gene mutations are result in frontonasal dysplasia. One of the peculiarities of facial anthropometry of Minangkabau women is the wide intercanthus distance when compared to Javanese and Batak women. A descriptive observational study was conducted on Down Syndrome patients and Minangkabau ethnicity aged 10-29 years who met the criteria as control. Data sampling of this study are taken by purposive sampling. Facial analysis using Rhinobase software. To examine the biomolecular analysis of ALX3 gene polymorphisms, sequencing was carried out using the Polymerase Chain Reaction (PCR) method. The average age of the sample was 17.7±4.8 years with 73% of the sample being male. There were significant differences in 14 of the 21 facial parameters. There was no significant difference in the En-En parameter with the mean intercanthus distance of the control group (39.25 mm) being greater than that of the SD group (38.07 mm). PCR examination results showed no polymorphisms were found in the ALX3 (rs121908169, rs121908168, rs387906319, rs121908170) and ALX3 (rs1570936479, rs121908166, rs34775503) genes in both groups. The largest distribution of samples based on gender was male. No significant difference found in the En-En parameter between the SD group and the control group. There were significant differences in 14 of the 21 facial parameters. There are no polymorphisms were found in the ALX3 in both groups.