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Abstract : The aim of this study is to compare two methods of treating temporomandibular joint disc displacement: the TMJ double needle arthrocentesis technique and the anterior repositioning splint. The sample included 20 patients diagnosed using T1 MRI to confirm the diagnosis. Clinical history was taken, symptoms were recorded, and the sample was divided into two groups: 10 patients who underwent the TMJ double needle arthrocentesis technique and 10 patients who underwent the anterior repositioning splint. Follow-up assessments were conducted after one week, one month, and three months. The results demonstrated improvements in pain and joint click sound in both groups, with the anterior repositioning splint showing superior results at the 12-week mark. Additionally, it was observed that there was no increase in the amount of mouth opening in patients who underwent the TMJ double needle arthrocentesis technique, whereas patients who underwent the anterior repositioning splint showed a slight increase in the amount of mouth opening. We conclude that both the anterior repositioning splint and arthrocentesis TMJ are effective in reducing jaw popping in cases of disc displacement with reduction, with the splint demonstrating superiority at week 12 of treatment. Additionally, arthrocentesis TMJ did not lead to increased mouth opening in cases of reduced TMJ dislocations, whereas the splint contributed to a slight improvement in this aspect.

Abstract : The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapid worldwide expansion. So far, there is no efficacious therapy for its treatment. Consequently, it is peremptory to identify certain clinical features & laboratory findings for monitoring the disease progression and early diagnosis of patients. To investigate and correlate the variations of the demographic, clinical and laboratory markers based on the severity of COVID-19 and their role in tracing disease progression. This observational analysis included 5016 patients of either gender, aged ≥ 18 years with mild, moderate and severe COVID-19. Data regarding age, gender, medical history, clinical and laboratory data was recovered from medical records of these patients. The retrieved study variables related clinical features & laboratory details like N/L ratio, complete blood count, renal function test, coagulation profile, blood sugars, serum electrolytes etc. were evaluated. The study population showed a male predominance (i.e., 63%) and 68.2% of the COVID population were of mild severity. The main two presenting symptoms were fever (69.3) and cough (36.9%). A significant difference (p<0.05) in the distribution of age, gender and outcome over COVID severity was noted. Also, significant differences (p < 0.001) were noted in many demographic, clinical, and serological parameters between all possible pairs of COVID severity. The COVID-19 severity is associated with specific clinical & deranged laboratory profile. Hence keeping a track of these clinical features & laboratory markers might allow early identification and disease progression prediction.

Abstract : The early-onset colorectal cancer (EO-CRC) prevalence has been steadily rising worldwide, which has led to it becoming a major public health concern. This condition may be a distinct entity with a higher degree of aggression based on its clinical, genetic, molecular, and histological features. However, it seems that the observed epidemiological change in the incidence of colorectal cancer (CRC) is influenced by both environmental and genetic risk factors. To clarify the aetiology of EO-CRC and develop efficient screening and management strategies, more data is needed. Given that colorectal cancer may cause the greatest loss of years of life in this demographic at the time of diagnosis, managing the disease in young adults represents an unmet clinical need. Since early 1990, the yearly incidence of colorectal cancer (CRC) in individuals under 50 has increased at a rate of 2%. Particularly concerning is the rise in the disease's incidence among young adults, as the overall frequency of CRC has been declining. The left side of the colon is home to the primary tumour of early-onset colorectal cancer (CRC), which is linked to worse cell differentiation, a higher incidence of signet ring cell histology, and an advanced stage at diagnosis. About 30% of patients have tumours containing mutations that result in hereditary cancer predisposing syndromes, and 20% of patients have familial colorectal cancer (CRC). About 30% of patients have tumours containing mutations that result in hereditary cancer predisposing syndromes, and 20% of patients have familial colorectal cancer (CRC).

Abstract : The nursing metaparadigm is a conceptual framework that defines the nature of nursing. It was introduced to the nursing profession by Jacqueline Fawcett. Traditional approaches in nursing education perpetuated oppressive aspects of the profession in terms of gender, occupation, and class. Developments in the field have led to alternative approaches which seek to emancipate nurses. The fundamental basis of these approaches is critical social theory, which aims to liberate groups from that impedes participation in social interaction. This study seeks to explain and compare Paulo Freire and Jurgen Habermas's theory on the concept of nursing metaparadigm, which include: person, environment, health, and nursing. This is a theoretical paper that utilizes theoretical, philosophical, and empirical literature on critical social theory by Paulo Freire and Jurgen Habermas respectively on the concept of nursing metaparadigm. The application of critical social theory in nursing education can be associated with professional growth and development. Critical engagement is a means towards knowledge development and emancipation of nursing. Knowledge and understanding of the broader context within which nursing exists, from a critical social theory perspective, may lead to continued improvements in inpatient care.

Abstract : The current study aims to compare the experience of a single center in a low-income country that uses both laparoscopic and laparotomy techniques to treat early-stage EC. This retrospective study was realized at Azerbaijan Medical University, Department of Oncology. The files of 117 endometrial cancer patients who underwent surgical treatment between 2018 and 2024 were retrospectively evaluated. TH, BSO, and LND (total laparoscopic hysterectomy with bilateral salpingo-oophorectomy and lymph node dissection) are the required procedures for the staging process. TH and BSO were administered to all individuals. One hundred and seventeen patients were treated and observed for endometrial cancer as long as the study period lasted. Twenty-two patients (18.8%) had a laparotomy, and 95 patients (81.2%) had laparoscopic surgery. In both groups, the longest observation duration was 77 months. Twelve patients (12.6%) experienced recurrence in the laparoscopy group, compared with 3 patients (14.3%) in the laparotomy group. During the follow-up period, survival data were gathered, and they revealed no significant differences (87.4% versus 85.7%). According to our study, laparoscopy plays an important role in the treatment of uterine-confined EC. In these cases, laparoscopic surgery may be conducted with a comparable level of lymph node dissection to laparotomy, a shorter hospital stay, and fewer postoperative infections. Although it is important to confirm the results of our study with prospective randomized controlled studies, our results can be a valuable reference in clinical settings. MIS should be encouraged in the treatment of EC nowadays in all low-income countries.