Abstract : Enhanced Recovery after Surgery (ERAS) protocols have revolutionized preoperative care, emphasizing interdisciplinary approaches to optimize patient outcomes. Despite growing implementation, significant variations persist in protocol effectiveness and adoption across surgical specialties. To systematically evaluate the implementation, barriers, and outcomes of ERAS protocols across multiple surgical disciplines, with a focus on identifying key strategies for successful multidisciplinary implementation. Study Design: Comprehensive systematic review and meta-analysis, with Data Sources from Multiple databases (PubMed, Scopus, and Cochrane Library). The Inclusion Criteria include Peer-reviewed studies on ERAS protocols from 2010-2024. And the Analysis method includes Mixed-methods approach combining quantitative and qualitative assessment. Key Components of Analysis include; Barriers to ERAS implementation, Multidisciplinary team effectiveness, Patient outcome comparisons, and Implementation strategies. The Total studies reviewed were 247 studies. With Surgical specialties covered include; Colorectal, Orthopedic, Urological, and Gynecological. Standardized Data Extraction includes; Quality assessment using modified GRADE methodology. And the Statistical Analysis includes: Descriptive statistics, Subgroup analyses, and Heterogeneity assessment. Significant variability in ERAS protocol implementation, Multidisciplinary approaches show improved: Patient recovery times, Complication rates, and Patient satisfaction. The ongoing evolution of ERAS protocols represents a critical advancement in surgical care. By embracing a holistic, interdisciplinary approach, these protocols promise to transform patient experiences, reduce surgical complications, and optimize recovery processes. This study seeks to contribute to this ongoing scientific dialogue by providing a comprehensive analysis of ERAS implementation strategies.