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Abstract : War is one of the most severe stress factors that can lead to anxiety-depressive disorders, cognitive, behavioral, and emotional dysfunctions. 106 students of the I-III courses of the Poltava State Medical University participated in the study of the personal students` characteristics of overcoming military stress in the conditions of a full-scale war in Ukraine. Based on the research results a low level of stress resistance was found in 36.7±0.3% of students, and a marginal level – in 47.2±0.3%. Students with a low degree of stress resistance demonstrated a high degree of stress load against the background of the predominance of the formation of maladaptive strategies of coping behavior, therefore they belong to the risk group of the development of psychosomatic disorders and adaptation disorders, they need psychological support in order to optimize the psychological resources of the individual to successfully cope with the state of stress, minimizing its negative impact, forming sustainable methods of protective behavior and coping, which in turn will be a guarantee of preserving the health of future employees of the health care system. The ability to effectively cope with stressful situations, using resources of stress resistance, will help students not only to be socially-adapted individuals who make responsible decisions in professional activities and effectively interact with people, but also to maintain health by giving up destructive ways of coping with stress.

Abstract : Medication-related osteonecrosis of the jaw (MRONJ) is a severe condition that can develop in persons who take antiresorptive agents such as bisphosphonates, Denosumab, or antiangiogenic therapies. Moreover, that is used to treat cancer or Osteoporosis. The primary goal is to identify the most compelling new treatment options to promote and fasten healing periods and review all approaches to managing patients with medication-related jaw osteonecrosis. To evaluate the advantage of using platelet-rich plasma or low-level laser in combination with surgery as new options in managing extraction sites or unhealed surgical wounds in patients taking medication-related osteonecrosis of the jaw. And trying to concentrate on the practical maneuvers s in the literature regarding the management of MRONJ in an attempt to set an algorithm for managing this condition. We performed a literature review. An electronic search was done in PubMed and google scholar using the keywords: medication-related osteonecrosis of the jaw, platelet-rich plasma, low-level laser therapy, hyperbaric oxygen therapy, and Teriparatide. Articles from 2005 to 2022 were included in the review. The management options were divided into conservative, surgical, and combination therapy. A specific treatment protocol to manage MRONJ is still missing. Over the years, several treatment options have been proposed, including; conservative management (antibiotics, analgesics, oral hygiene), a surgical procedure that includes (debridement, curettage, and resection) and modern options Like (platelet-rich plasma, low-level laser therapy, hyperbaric oxygen therapy, Teriparatide dug) combined with surgery or along. Early or low-grade MRONJ can be managed conservatively. In advanced or refractory medication-related osteonecrosis of the jaw (pathological fracture, percutaneous fistula), surgical treatment, at present, remains the only treatment option available, but using a combination of treatment options that we mentioned above with surgical procedure can promote and fasten treatment periods.

Abstract : A global pandemic, diabetes mellitus DM is growing in prevalence and importance. Many pathogenic pathways contribute to the onset of this disease, and these processes may be impacted by genetic, epigenetic, and environmental factors. Protein glycation processes that are non-enzymatic have been closely linked to the development of chronic complications due to diabetes. Fructosamine 3-kinase has been identified (FN3K), A new method of protein repair called protein deglycation involves an enzyme that is of tremendous interest. Fructosamines become unstable and separate from proteins when FN3K phosphorylates them on the third carbon of their sugar moiety. Here we argue about enzyme activity and its comparison in control group and patients with type 2 diabetes and enzyme activity in control group according to sex, age and BMI and about the existence of an inverse relationship between activity of enzyme and glycated hemoglobin also Comparison of clinical parameters Include Insulin, insulin resistance, HbA1c and Fructosamine between control and DM type 2.

Abstract : Medication-related osteonecrosis of the jaw (MRONJ) is a severe condition that can develop in persons who take antiresorptive agents such as bisphosphonates, Denosumab, or antiangiogenic therapies. Moreover, that is used to treat cancer or Osteoporosis. The primary goal is to identify the most compelling new treatment options to promote and fasten healing periods and review all approaches to managing patients with medication-related jaw osteonecrosis. To evaluate the advantage of using platelet-rich plasma or low-level laser in combination with surgery as new options in managing extraction sites or unhealed surgical wounds in patients taking medication-related osteonecrosis of the jaw. And trying to concentrate on the practical maneuvers s in the literature regarding the management of MRONJ in an attempt to set an algorithm for managing this condition. We performed a literature review. An electronic search was done in PubMed and google scholar using the keywords: medication-related osteonecrosis of the jaw, platelet-rich plasma, low-level laser therapy, hyperbaric oxygen therapy, and Teriparatide. Articles from 2005 to 2022 were included in the review. The management options were divided into conservative, surgical, and combination therapy. A specific treatment protocol to manage MRONJ is still missing. Over the years, several treatment options have been proposed, including; conservative management (antibiotics, analgesics, oral hygiene), a surgical procedure that includes (debridement, curettage, and resection) and modern options Like (platelet-rich plasma, low-level laser therapy, hyperbaric oxygen therapy, Teriparatide dug) combined with surgery or along. Early or low-grade MRONJ can be managed conservatively. In advanced or refractory medication-related osteonecrosis of the jaw (pathological fracture, percutaneous fistula), surgical treatment, at present, remains the only treatment option available, but using a combination of treatment options that we mentioned above with surgical procedure can promote and fasten treatment periods.

Abstract : The aim of this study was to evaluate the effect of low-level laser irradiation in accelerating tooth movement along with self-ligating brackets in dento-alveolar posterior bilateral cross bite correction in adults. Thirty one patients (mean age: 18-25 years) with bilateral posterior crossbite of dento-alveolar origin, Split mouth design was performed and followed, Each upper arch was divided into two sides (experimental and control). Separation rubber was applied for a week then attach the orthodontic brackets and bands and 0.013-in archwire was applied. The laser was applied to the experimental side with a wavelength of 830 nm in a continuous mode (energy density, 1 J/cm2) on 3 points buccally and palatally around each root of upper first and second premolar and upper first molar on the experimental side; the other side was designated as the control with nontherapeutic light applied. Laser irradiation was applied at baseline and then on the 3rd, 7th, 14th, 21th day after that repeated every mouth until the crossbite corrected. A CBCT image of the upper jaw was taken after the two ends came out of the dental alveolar crossbite to assess the changes in the thickness of vestibular alveolar bone and degree of torque on upper first molar and first, second premolar before and after treatment on both sides. The thickness of vestibular alveolar bone on upper first and second premolar and first molar before the treatment was significantly different after treatment on both the experimental and control sides (p<0.05), the same was for the degree of torque on upper first and second premolar and first molar on both sides. The thickness of vestibular alveolar bone and degree of torque on upper first and second premolar and first molar was nonsignificant (p > 0.05) between the two sides before and after treatment. Within the limitation of this study we can conclude that the laser did not have an additional role in increasing treatment efficacy and the self-ligating brackets were effective in correcting posterior crossbite by widening the upper arch.