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Abstract : The Healthy District Program has been officially and systematically effective since the issuance of a Joint Regulation between the Ministry of Home Affairs and the Ministry of Health in 2005. Meanwhile, the implementation of this program in Pangkep Regency began in 2007. The purpose of this study was to analyze the implementation of such a program in the Pangkep Regency. This research was descriptive with a qualitative approach. The data were collected using in-depth interviews and document reviews. Ten informants were involved in the research. Content analysis was used to analyze the data. The findings showed that communication was carried out well within the scope of the advisory and healthy district forum teams. However, it could still be maximized to reach the community. Regarding resources, the staff (advisory and healthy district forum teams) performed quite well. However, it was found that the level of participation decreased, and some staff had excessive workloads. Regarding the facilities and infrastructure, secretariat offices were there to support the program. However, there were budget constraints for regional organizations in achieving healthy district indicators and for the teams’ incentives. The implementation of the healthy district program in Pangkep district has so far been carried out well in terms of communication and resources. However, in its implementation, a sectoral ego was found. Therefore, for the successful implementation of a healthy district program in Pangkep district, this program is led directly by the Regent or Regional Secretary to align with the Regional Head's vision and mission.

Abstract : The culture of drinking alcohol which is done by men and women in activities related to traditional events has grown into a habit for Maluku People. The purpose of this study is to investigate the effects of alcohol and non-alcohol consumption on women in Solea Village, East Taniwel District, West Seram Regency, Maluku Province. This is a quantitative study with an analytical study design and a cross sectional approach. A sample of 124 people was divided into 62 who consume alcohol and 62 who do not. In this study, the significant value on health impact and social impact was <0.001, while the economic impact was 0.250. So it can be concluded that there is difference in health impact and social impact on alcohol consumption habit and non-alcohol consumption, while on economic impacts it is concluded that there is no difference in economic impact on alcohol consumption habit and non-alcohol consumption. it is recommended for women in Solea Village to be more active in doing positive activities so that they can avoid alcohol and be more active in looking for information about the impact of consuming alcohol.

Abstract : Minimum Service Standard (MSS) for health is a reference for Regional Government to provide Health Services that every citizen deserves to receive minimally. This study aimed to analyze the implementation of Minimum Service Standard for pregnant women's health service in South Konawe Regency. The research design used a case study method with a qualitative-explorative approach through observation, in-depth interviews and literature studies of all research informants that selected by purposive sampling. The variables of this study used the theory of policy implementation by Edward III (1980) including: communication, resources, disposition and bureaucratic structure. The results of this study indicate that communication has not run optimally, information is not clear and detailed. The elements of transmission and consistency are good, but the element of clarity is not running optimally. Resources are still inadequate, human resources are available as needed, but Human Resource capabilities are still not optimal, budget is still limited, and there are still problems that related to support health facilities. Disposition has been going pretty well. commitment and implementation support are quite good, it has carried out coordination and commitment that involve cross-program and related cross-sectors. The bureaucratic structure is already running quite well. The implementation of Minimum Service Standard for pregnant women's health services in South Konawe Regency has is already running quite well. It is hoped that the health office, Public Health Center, local government of South Konawe Regency will improve aspects of communication, resources, disposition and bureaucratic structure in their implementation.

Abstract : Single nucleotide polymorphisms (SNPs) play a crucial role in distinguishing disease-prone individuals. Identifying SNPs that affect protein stability is crucial. IRAK1 is one of the genes associated with Systemic Lupus Erythematosus susceptibility (SLE). This study aimed to identify nsSNPs within the IRAK1 gene that influence protein structure and function as a risk factor for SLE disease. Several in silico servers were used, including SIFT, PolyPhenv2, PROVEAN, SNAP, PhD-SNP, and Panther. Furthermore, nsSNPs identified as potentially harmful were investigated further using I-Mutant. The GeneMania server was used to identify gene interactions in order to determine whether the effect of existing polymorphisms was due to interactions with other genetic factors. Four nsSNPs with missense mutations in the human IRAK1 gene were identified: rs10127175, rs11465830, rs1059702, and rs1059703. Using the SIFT server, each of the four nsSNPs is tolerant. The Polyphen server's results demonstrated that the four SNPs were all benign. According to server data from Provean, four SNPs were all neutral. The SNAP server resulted one SNP to have no effect and three others to have an effect. Four SNPs on the PhD-SNP server were neutral. The Panther server yielded four SNPs all likely benign. According to the I-Mutant server analysis, four SNPs have the potential to reduce protein stability (decrease). There are nsSNPs of the IRAK1 gene, rs10127175, rs11465830, rs1059702, and rs1059703, that impair protein stability and are risk factors for SLE disease.

Abstract : Kidney donations are fraught with psychological distress, leading to significant depression and anxiety. This case report highlights a potential donor undergoing psychological assessment as part of the Kidney transplant assessment by the Consultation-liaison psychiatry team. This potential donor is a biological sibling of the recipient and was second in line after another sibling was rejected. As part of the transplant assessment, he was referred to the consultation-liaison psychiatry (CL) team for a psychological assessment. En Z was seen on the 12th October 2022. His Depression, Anxiety, and Stress Scale (DASS) score were 4 (Anxiety component -normal). Upon review, he has no psychopathology or psychiatric diagnosis. He had an adequate understanding of the benefits and risks of the procedure to make an informed consent. There was no coercion or manipulation in his voluntary decision. He had psychosocial preparation, including a care plan during the postoperative period, with good emotional and financial support from his family. He understood the importance of maintaining a healthy lifestyle post-operation. Hence the team deemed him psychologically fit for the operation. Organ donation can impact the mental and physical well-being of living donors, and often, the mental health of donors is overlooked. All potential kidney donors undergo pre-donation assessment, psychological assessment, surgical assessment, and post-donation care plans curated by the transplant society. Hence, donors’ mental health and physical well-being cannot be overlooked as they are providing the gift of life to the recipients. Throughout their journey, emphasis should be made on adequate psychosocial support for them and maintaining a good quality of life with the appropriate support and interventions.