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Abstract : In this study, the nanotreatment of industrial wastewater was used, which included industrial machinery cooling waste water, dairy waste water, and copper industry water. Nanoremediation involves the use of nanoparticles of zinc oxide (ZnO). They are water-insoluble particles, which have been highlighted in water treatment including industrial wastewater contaminated with toxic metals. Different concentrations of zinc oxide nanoparticles were used, ranging from (0.1 mg/L) to (1g/100 mL). They were added to solutions of concentrations of each of the following elements: lead (750) mg/ L, copper (250 mg/L), and nickel (500. mg/L), and chromium (250 mg / L) in order to identify the optimal concentration in the process of removing heavy metals. The results were obtained by measuring the remaining concentrations of ions of each of the heavy elements (lead, copper, nickel, chromium), and high removal rates were obtained using nanoparticles of zinc oxide (ZnO).

Abstract : Mangrove Crab or Scylla Serrata is a source of biodiversity whose habitat is in the mangrove forest in Kayeli Bay which generally grows and develops in coastal areas. Unlicensed gold mining activities on Buru Island resulted in mercury being deposited at the bottom of the river and the waters of Kayeli Bay. This will increase the potential for bioaccumulation and bioconcentration of mercury in mangrove crabs. The purpose of the Research is to determine the level of accumulation of heavy metal Hg in mud crabs and to analyze the health risks to the community through the consumption of mud crabs in Kaki Air Village, Kayeli Bay District, Buru Regency. The method that the researcher used is descriptive analysis with the Environmental Health Risk Analysis approach, questionnaires, laboratory examinations, and calculations, to determine the level of public health risk, the sample in this study was 80 people who lived in Kaki Air Village and consumed mud crabs, 16 samples of mud crabs were analyzed for Hg levels then the Intake (I) and Risk Quotient ( RQ) based on risk agent concentration, rate of intake, frequency of exposure, duration of exposure, and body weight using the Environmental Health Risk Analysis formula. The results showed that the Hg levels in mud crabs were as high as 0.0006 mg/kg, the Intake (I) value does not exceed the reference dose (RfD) the Risk Quotient (RQ) value of the 20-30 year projection ranges from 1.0435E+000, 1.3044E+000 to 1.5653E+000, unsafe and risky, this means RQ> 1 (risk needs to be controlled). The results of the analysis show that the people of Kaki Air Village, Kayeli Bay District, have a risk of non-carcinogenic health problems due to mercury exposure through consumption of mud crabs, at risk of body weight 63 kg, with an age of 39 years, intake rate of 170 gr/day, and frequency of 48 days/day. years, in the next 20 to 30 years, assuming that the source of exposure only comes from mangrove crabs and does not take into account other heavy metal exposures from other sources.

Abstract : Wounds were a challenging clinical problem that often caused morbidity and mortality. Apium graveolens (Linn.) was an herbal plant that had anti-oxidant and anti-inflammatory effects which were considered to accelerate the wound healing process. The number of neutrophils and angiogenesis was an element that played an important role in the wound healing process. Thus, the administration of Apium graveolens (Linn.) extract was expected to help in the process of wound healing which could be viewed from the number of neutrophils and angiogenesis. To determine the effect of giving Apium graveolens (Linn.) extract on the number of neutrophils and angiogenesis in incisional wounds of Sprague Dawley rat. This study was an experimental study with "Randomized post test with control group" design in rats given incisional wounds on their backs, and randomly divided into 4 groups (@5 rat). The number of neutrophils and angiogenesis were seen microscopically and assessed by 2 certified pathologists. The data were analyzed using the One Way Anova - Post Hoc hypothesis test. The number of neutrophils and angiogenesis in the Apium graveolens (Linn.) extract group was significantly lower than the group given the cream without extract (p <0.05) and no difference compared to the group given gentamicin 0.1% cream (p >0.05). The group with Apium graveolens (Linn.) extract 70% had the lowest number of neutrophils and angiogenesis compared to other groups (p <0.05). The application of the topical Apium graveolens (Linn.) extract is effective in the incisional wound healing process by decreasing the number of neutrophils and angiogenesis. The application of the topical Apium graveolens (Linn.) extract 70% is more effective than the extract 50%.

Abstract : Perimembranous Ventricular Septal Defect (PmVSD) is one of the most common type of congenital heart abnormality. Transcatheter closure of PmVSD is an emerging alternative modality to surgical closure, but has high radiation exposure. We reported a transcatheter VSD closure in PmVSD’s patient through femoral venous route under the guidance of Trans-Esophageal Echocardiography (TEE), without fluoroscopy. The catheter’s delivery and device deployment guided by long axis and short axis TEE’s view. The procedure was success without any complication. Transcatheter device closure of VSD under TEE guidance without fluoroscopy is effective and safe.

Abstract : Diabetes mellitus and its complications like peripheral neuropathy are priority non-communicable diseases that the number of patients increased over time. This condition will result in a progressive decrease in the life quality of patients. Controlled risk factors to decrease quality of life needs to be done, one of the most important risk factors is a lifestyle. This study was to create a prediction model of quality of life-based on lifestyle in type 2 diabetes mellitus patients with peripheral neuropathy. The study was cross-sectional. 210 patients with diabetes mellitus type 2 were applied in this study using purposive sampling. Data were carried out using a self-developed questionnaire by the research team and which met the existing validity and reliability requirements. Data were analyzed using SEM PLS. Variables that have a direct influence on the quality of life are social interaction (r=0.563; T=10.591; p=0.0001; f²=0.544), self-care (r=0.236; T=4.769; p=0.0001; f²=0.093) and eating patterns (r=0.236; T=3.947;p=0.0001; f²= 0.095). Variables that have an indirect effect on the quality of life are physical activity variables (r= -0.063; T= 2.981; p= 0.003; f²=0.074) and sleep pattern variables (r= 0.058; T= 2.851; p= 0.005; f²= 0.063). The R square value of the predictor variable with a moderate category of quality of life (R square = 0.496). All the variables in this prediction model have a Q-square value of more than 0.02 so it can be stated that all the variables that make up the model are declared good. This predictive model is feasible in explaining the influence between variables (SRMR value = 0.99). A prediction model was formed consisting of 5 predictor variables, namely social interaction, self-care, eating patterns, physical activity, and sleep patterns.