Azerbaijan Medical Journal

PD-1 as a predictor of antitumor immune resistance Its detection perspectives and correction possibilites in cervical cancer

Abstract :

Cervical cancer is one of the most common gynecological tumors, and the majority of early-stage cervical cancer patients achieve good recovery through surgical treatment and concurrent chemo radiotherapy (CCRT). However, for patients with recurrent, persistent, metastatic cervical cancer, effective treatment is rare, except for bevacizumab combined with chemotherapy. Programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) inhibitors might be a novel choice to improve the clinical

Assessment of the lipid profile correction in patients with arterial hypertension and type 2 diabetes mellitus

Abstract :

Previous studies have shown that diabetes mellitus (DM) increases the risk of cardiovascular diseases in females to a greater extent than in males. In this cross-sectional study, we evaluated the lipid profiles of type 2 diabetic males and females. Materials and Methods: The study included 107 type 2 diabetic patients (41 males and 66 females), and 122 hypertensive type 2 diabetic patients (39 males and 83 females), aged 15 years and older. Total cholesterol (TC), triglycerides (TG), low dens

The role of the Vitamin D / parathormone system in the pathogenesis of bone metabolism disorders in rheumatoid arthritis

Abstract :

Osteoporosis is a well-established extra-articular feature of rheumatoid arthritis (RA). Systemic inflammation seems to play a crucial role in causing an alteration of multiple homeostatic systems implied in bone health, such as the RANK/RANKL/Osteoprotegerin and Wnt/ catenin pathways several other causal factors have been called into question, including the chronic use of corticosteroids. Since vitamin D exerts important immune-regulatory roles, it has been claimed that derangement of the vi

Changes of cytokine profile in the blood of pregnant women with anemia

Abstract :

The aim of this study was to investigate the level of serum cytokines in different periods of pregnancy associated with anemia. 85 pregnant patients with anemia were examined. 46 of them were in their first pregnancy (1st group), and 39 (2nd group) patients were in their second or further pregnancy period. The comparison group consisted of 19 pregnant women without anemia. The level of hemoglobin and serum iron were determined by using colorimetric method, as well as the level of cytokines IL

FCGR2C family moleculars and development of autume process in haimimoto tyroiditis

Abstract :

FCGR2C gene was investigated at first time in Hashimoto disease. The aim of this study is to show with genotype-phenotype correlation analysis of the clinical phenotypic role in autoimmune disease of Hashimoto's thyroiditis of nucleotide polymorphisms or variations in the nature of mutations in FcGR2C gene, responsible for the production of proteins which have an extremely active role in immune system. The study group comprised by 48 patients admitted to Department of Endokrinology of Ege

Comparative assessment of magnesium deficiency in patients with beta thalassemia

Abstract :

Regular blood transfusion and iron chelation is the primary treatment of thalassemia patientsto maintain their life. Iron chelatormay alter serum total calcium and magnesium level in TDT patients. To evaluateany alteration of serum total calcium and magnesium level in transfusion dependent thalassemia patients treated with iron chelator. The present cross sectional study was carried out in the department of Physiology, BSMMU, Dhaka between September 2017 to February 2019. Thirty cases of TDT,

The role of antimicrobial peptides in the pathogenesis of diabetic glomerulopathy

Abstract :

Autoimmune diseases (AiDs) are characterized by the destruction of host tissues by the host immune system. The etiology of AiDs is complex, with the implication of multiple genetic defects and various environmental factors (pathogens, antibiotic use, pollutants, stress, and diet). The interaction between these two compartments results in the rupture of tolerance against self-antigens and the unwanted activation of the immune system. Thanks to animal models, the immunopathology of many AiDs is

Effectiveness of use of rituximab in treatment of steroid-resistant nephrotic syndrome

Abstract :

Childhood nephrotic syndrome is a challenging and often persistent renal disorder, and its incidence varies between different ethnicities and regions. Corticosteroids have been the main treatment for decades and are effective in most children with idiopathic NS, although 10–15% of these children become steroid resistant. Furthermore, some initially steroid sensitive children follow a steroid dependent or frequently relapsing course and are therefore at increased risk for developing ster

Role of respiratory system in adaptation of sportsmen to intensive physical activities

Abstract :

Recent studies demonstrated that current European Respiratory Society/American Thoracic Society spirometric reference equations, used in general population, may not be applicable in population of elite athletes. Althought it is well known that physical activity may affect lung volumes, the effect of sporting activity on pulmonary function testing indices was never examined. The aim of this study was to examine the differences in functional respiratory parameters in various types of sports by

Prevalence of thyroid cancer in patients with nodular goiter

Abstract :