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Abstract : Intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) can observe not only the diffusion of tissue water molecules, but also the blood perfusion information of tissue microcirculation. IVIM-DWI has been utilised in numerous clinical settings. However, few studies have addressed the use of IVIM-DWI for assessing the response of hepatocellular carcinoma (HCC) patients to locoregional therapy. The purpose of this study was to investigate the role of IVIM-DWI in the therapeutic efficacy of HCC locoregional therapy. Three weeks before and three weeks after tranarterial chemoembolisation, IVIM-DWI scans were performed on 30 patients using a 3.0T magnetic resonance imaging device. Standard apparent diffusion coefficient (ADC), pure diffusion coefficient (Dslow), pseudo-diffusion coefficient (Dfast), and perfusion fraction () values were measured. Using paired t tests, the values of IVIM-DWI parameters before and after TACE were compared. The responsive and non-responsive groups' values were compared using a t-test for independent samples. P < 0.05 indicated statistical significance. After TACE, the ADC and Dslow values in the tumours increased significantly, whereas the Dfast values decreased significantly, while the f value did not significantly change. The ADC values in the responsive group were significantly greater than those in the non-responsive group, while the Dfast values in the responsive group were significantly lower than those in the non-responsive group. However, the values of Dfast and f did not differ significantly between the two groups. IVIM-DWI parameters can be used as potential therapeutic response markers for TACE treatment of HCC.