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Abstract : Coronary artery disease (CAD) is more prevalent among the Indian population with significant morbidity and mortality. Various inflammatory and lipid markers are available for the diagnosis of CAD but with huge cost. Recently uric acid has been found to play a significant role in the progression of CAD. So the present study was done to find the diagnostic ability uric acid to high density lipoprotein cholesterol ratio in the prediction of CAD. This was a case control study done on forty patients and they were designated as cases (n=20), patients diagnosed with CAD and controls (n=20) who were healthy volunteers. Various biochemical markers such as lipid, liver and kidney profiles, uric acid and UHR levels were analyzed. Unpaired student t test was used to compare between the groups. Receivers operating curve was performed to find the diagnostic accuracy. In this study, the lipid profiles were significantly elevated in cases as compared to controls. The UHR levels were elevated in cases as compared and it was significant (0.19 ±0.008 vs 0.08 ± 0.001 p=0.00001. Based on the ROC curve the sensitivity and specificity for UHR for cut off value of 11 was found to be 90% and 90%. UHR is a cheap and effective diagnostic marker in the prediction of CAD and it can be used in all healthcare facilities.