Abstract : Public perception of COVID-19 vaccination is pivotal for the success of the vaccination program as it influences individual decisions and community health outcomes. By utilizing the Health Belief Model (HBM), this comprehensive study examined perceptions among a diverse sample of 92 respondents, aged 17 to 65 in Minahasa Regency, North Sulawesi Province in 2022. This study was carried out using a cross-sectional design. The data was collected by administering questionnaire assessing respondents’ sociodemographic characteristics and five dimensions of perceptions of COVID-19 vaccination, including perceptions of vulnerability, severity, benefits, barriers, and perceptions based on cues to action. Findings revealed predominantly positive perceptions concerning vulnerability to COVID-19 (69.6%), severity of the disease (77.2%), and benefits of vaccination (66.3%). However, negative perceptions were observed regarding barriers to vaccination (51.1%), indicating potential challenges in uptake. Notably, a significant majority (81.5%) expressed willingness to undergo vaccination, signaling a positive inclination towards immunization efforts. These perceptions were found to significantly influence vaccination acceptance rates in the regency, with perceived barriers emerging as a key factor hindering uptake. Understanding and addressing these perceptions are essential for the development and implementation of effective vaccination strategies and public health interventions aimed at combating COVID-19 in the region.