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Abstract : Ovarian cancer (OC) is one of the most lethal gynecological cancers, typically presenting at advanced stages of the disease with abdominal and pelvic cavity involvement. The management of these patients is often very challenging, with low survival and high relapse rates. Cytoreductive surgery, chemotherapy, and target therapy play the leading roles in treating OC patients. This review paper investigated the historical, present, and possible future role of radiation therapy (RT) in managing OC patients. The studies published from January 2013 (with some representative historical studies) were reviewed using PubMed (Medline), Scopus, Web of knowledge, the Cochrane Library, and Embase databases. High-quality studies with complete data and statistically significant and representative results were selected for the review. In the review paper, the historical application of whole abdominal radiotherapy (WART) and radionuclide therapy using phosphorus-32 (32P) was outlined. These treatment modalities were excluded from clinical practice due to their high toxicity and poor therapeutic efficacy. To date, RT is considered a palliative option in selected patients with locally recurrent OC, especially when other available treatment modalities are expected to fail. Implementing new RT options with focal precise delivery of the therapy with minimal involvement of nearby organs (including SBRT and IMRT) involving radiosensitization and target therapy can lead to wider use of these treatment modalities in OC patients, possibly as a consolidating treatment option in patients with advanced OC.