Abstract : Medical students are a population at risk of experiencing various health problems, one of which is functional dyspepsia symptoms. The triggering factors for functional dyspepsia include stress and poor sleep quality. To determine the relationship between psychological stress and sleep quality with the incidence of functional dyspepsia in preclinical first-year students and first-year clinical students at the Faculty of Medicine, Syarif Hidayatullah State Islamic University, Jakarta. The design of this study was cross-sectional with 49 respondents from each sample group selected through the consecutive sampling method from first-year preclinical students and first-year clinical students at the Faculty of Medicine, State Islamic University (FK UIN) Syarif Hidayatullah Jakarta. This research design is cross-sectional with 49 respondents from each sample group selected through the consecutive sampling method from preclinical first-year students and first-year clinical students of FK UIN Syarif Hidayatullah Jakarta. The research instrument used a functional dyspepsia questionnaire based on the Rome IV Criteria, Depression Anxiety Stress Scales (DASS-21), and the Pittsburgh Sleep Quality Index (PSQI). From 49 first-year preclinical students, 42.9% had functional dyspepsia, with 83.3% of them having moderate-to-severe stress levels, and 90.5% having poor sleep quality. Meanwhile, in 49 first year clinical students, 24.5% experienced functional dyspepsia, with 71.4% of them having moderate-to-severe stress levels, and 100% having poor sleep quality. There was a significant relationship between psychological stress and functional dyspepsia in first year preclinical (p=0.001) and clinical (p=0.007) FK UIN Syarif Hidayatullah Jakarta students. However, there was no significant relationship between sleep quality and functional dyspepsia in preclinical (p=0.688) and clinical first-year students (p=0.090) Faculty of Medicine, UIN Syarif Hidayatullah Jakarta. There is a significant relationship between moderate-to-severe psychological stress in students of FK UIN Syarif Hidayatullah Jakarta in the first preclinical year and the first year of the clinic with the incidence of functional dyspepsia. On the other hand, there was no significant relationship between poor sleep quality and the incidence of functional dyspepsia for both medical students in the first preclinical year and in the first clinical year.