One of the natural immune responses of children who experience dengue infection is through the activation of vitamin D into an active form in the blood which plays a role in reducing viral load competitively against the body's viral receptors and helping macrophages to phagolisosomes of the dengue virus by increasing levels of cathelicidin through vitamin D receptors on macrophages and helping inhibit excessive release of pro-inflammatory mediators by the body. This study aims to relationship between vitamin D receptor gene polymorphisms and the degree of dengue virus infection. This study was an observational study with a cross-sectional design, where the dependent and independent variables were examined at the same time in pediatric patients who were hospitalized with clinical symptoms of dengue infection at Raden Mattaher Hospital Jambi and Baiturrahim Jambi Hospital who met the inclusion criteria with positive anti-dengue IgM. and or positive anti-dengue IgG. The results showed that there is a significant relationship between vitamin D levels and where there is an increase in the value of cathelicidin levels according to the degree of dengue virus infection in children. In this study it was concluded that the most influential levels between vitamin D levels and cathelicidin levels with the degree of dengue infection were cathelicidin levels.