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Abstract : Chronic kidney disease (CKD) is a serious health problem in children with increasing prevalence and mortality rate. One of the most common complications in CKD is anaemia. When the kidneys fail to function, erythropoietin (EPO) production decreases significantly and reduces red blood cells production in the bone marrow. There have been no studies looking for a link between severe CKD and iron deficiency anaemia in Indonesia. This study assessed the relationship between severe stage CKD and the prevalence of iron deficiency anaemia in children. This research was an observational analytic study with a cross-sectional design involving thirty children at progressed stage of CKD. Research was carried out at Haji Adam Malik hospital, Medan, Indonesia from January to March 2022. Iron status examination was carried out. The relationship between severe CKD and iron deficiency anaemia was analysed using Kruskal Wallis test. There were four (4/10, 40%) children with iron deficiency anaemia at stage 3A. Two (2/4, 50%) children at stage 3B had iron deficiency anaemia. One third of children at stage 4 had iron deficiency anaemia (1/3, 33.3%). Eight (8/13, 61.5%) children at stage 5 had iron deficiency anaemia. Kruskal Wallis analysis test did not show any relationship between CKD stage and iron deficiency anaemia (p = 0.711). Iron deficiency anaemia was more common in progressed stages of CKD, where stage 5 had the highest incidence of iron deficiency anaemia. However, this study showed no significant relationship between severe CKD and iron deficiency anaemia.