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Abstract : The skin is the largest organ in the body that provides protection to the body. UV radiation contributes about 80% to skin aging. This study aims to determine whether there is a relationship between the regular use of sunscreen with the severity of facial wrinkles, the amount of sebum, pigmentation and the size of pores. This study was an observational analytical study using a cross-sectional study design. Data processing and analysis will use the SPSS (Statistical Product and Service Solution) program. Then, the collected data will be edited, coded, and tabulated. Next, a hypothesis test will be carried out to see the magnitude of the variable relationship using univariate analysis and bivariate analysis. There were 45 female respondents aged 35 – 45 years at RT 007 RW 11 Cawang Village. Skin examination using Skin Analyzer tool: Dermosmart Viso. The results of the study obtained there was significant relationship between the regular use of sunscreen with the severity of facial wrinkles, one way to prevent skin damage with the use of sunscreen. There was no significant relationship between routine use of sunscreen and sebum levels because the use and selection of sunscreen by respondents have not been good and correct. There was no significant relationship between the regular use of sunscreen and pigmentation due to genetic and hormonal factors. It is found that significantly related between regular use of sunscreen and pores because sunscreen can inhibit the skin from losing MAGP-1 so that the pores do not enlarge.