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Abstract : Researchers believe genetic and environmental factors cause most cases of cleft lip and palate. However, the exact cause was not found. There is an assumption that cleft lip and palate condition has something to do with Tetralogy of Fallot in children with Gestational Diabetes Mothers. Then it is also found in babies with cleft lip and palate conditions, usually accompanied by other congenital anomalies, but not always. This then led to further speculation that there is a relationship between the above variables with cleft lip and palate. Therefore, this study tries to find the relationship between these variables. Objective, Knowing the Relationship between the incidence of Cleft Lip and Palate with Tetralogy of Fallot in Children with Gestational Diabetes. Methods this research is Sxystematic Review using Preferred Reporting Items for Systematic Reviews and Meta-analyses or PRISMA. This method is carried out systematically by following the correct research steps or protocols. The source was taken from the Google Scholar website with journals published in 2017-2023 and then carried out screening results obtained from 1870 journals. The Results show that Journal clustering was carried out, and the number of Q1 indexed journals were 4 journals, 1 journal Q3, and 1 journal Q4 so 6 journals were extracted. The entire journal does not directly discuss the relationship between research variables. However, it only provides an overview of the increased risk of cleft palate in babies if the pregnant mother has gestational diabetes, the possibility of having a baby with Tetralogy of Fallot, and the baby's association with conditions cleft lip and palate and tetralogy of Fallot.