Abstract :
Type 2 diabetes mellitus is an increasingly prevalent chronic healthcare condition with a range of systemic complications. Vitamin D is an essential micronutrient that has been associated with the pathogenesis of type two diabetes, specifically in reducing insulin resistance and systematic inflammation. Understanding the prevalence of Vitamin D deficiency in type two diabetes patients can significantly help in comprehending the gaps in the T2DM management protocols and can improve the management guidelines for patients with type two diabetes. This review paper focuses on the study of the prevalence and management of Vitamin D deficiency in patients with type two diabetes mellitus. English-language literature from January 2015 onwards was searched for studies conducted in both male and female patients with type two diabetes and vitamin D deficiency using PubMed (Medline), Scopus, Web of knowledge the Cochrane Library, and Embase databases. High-quality interventional studies with complete data and significant results were selected for the review. A total of 16 studies were included in the review. The review showed that vitamin D deficiency is highly prevalent in patients with T2DM worldwide and is directly associated with poor glycemic control. A considerable negative correlation between HbA1c and 25-hydroxyvitamin D was also observed (p < 0.001). However, an inconsistency in the effectiveness of vitamin D supplementation for the management of T2DM was observed. Vitamin D may significantly contribute to the onset and progression of type 2 diabetes; however, high-quality observational studies that evaluate serum 25-hydroxyvitamin D levels and clinically significant glycemic measures are required to better specify vitamin D's involvement in the onset and progression of T2DM.