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Abstract : This study examined the effect of Islamic spirituality intervention (rida, ruqya and rahma) on DM distress in uncontrolled type 2 DM patients. A quasi-experimental study were done in 80 patient with uncontrolled type 2 DM (n=40 intervention group, n=40 control group). The intervention group received Islamic spirituality intervention for 10 weeks. Spirituality scores and DM distress were measured before and after treatment. After the Islamic spirituality intervention, significant changes were found between the treatment group compared to the control group, including an increase in spirituality, a decrease in DM distress. We concluded the Islamic spirituality intervention (rida, ruqya and rahma) affects the reduction of DM distress in uncontrolled type 2 DM patients.