Abstract : Irisin is a new myokine generated in mice and humans by proteolytic cleavage of fibronectin, and it may also be released in tiny amounts by adipose tissue and the liver. Irisin acts as an adipokine and myokine hormone that is released after exercise. The present study aimed to know the effect of irisin values on the levels of white blood cells and their subsets, Thyroid hormones (T3&T4) and Thyroid stimulating hormone (TSH), immunoglobulin (IgG and IgM). About 100 volunteers are Iraqi women aged (18-38) years old, the 100 volunteers are classified into two groups. The first group is the women practicing sports, whose training lasts between 3 months and 1 year or more, which includes 80 volunteers, and the second group is the control group, those who are not playing any type of sport which includes 20 volunteers. The present study showed the level of irisin had a highly significant increase in women practicing sports more than control (p≤0.01) by using the ELISA kit. We found a highly significant increase (P≤0.01) in WBC (white blood cell) in women practicing sports compared to control women. When going for a thyroid function test, the present study found a significant increase (P<0.05) in T3 and T4 but a significant decrease (P<0.05) in TSH in women practicing sports in comparison to control. In immunity levels, the IgG and the IgM were found to have a highly significant increase (P<0.001) in women practicing sports in comparison to control. On the other hand, we found no significant difference (P≥ 0.05) in lymphocyte, eosinophil and basophil in women practicing sports, but in monocyte we found a significant decrease (P<0.05) in neutrophils we found a significant increase (P<0.05) in women practicing sports compared to control.