Abstract : The symptoms of celiac disease and irritable bowel syndrome (IBS) are similar, and could be confusing; however, a correct diagnosis is highly important because the treatment is different. Literature assessing celiac disease among patients with IBS is scarce. We assessed the prevalence of celiac disease among patients with IBS. We searched PubMed/MEDLINE, Cochrane Library, and Google Scholar during March and April 2024. All articles investigating celiac disease/irritable bowel syndrome overlapping from 2011 to April 2024 were eligible. The terms celiac disease, gluten enteropathy, gluten sensitivity, and irritable bowel syndrome were applied. The author's name, year of publication, country, and patient number in the control and interventional group were collected using predetermined tables, and the RevMan system version 5.4 was used for meta-analysis. Out of the 978 articles retrieved, 30 full texts were screened, and 10 studies with 9395 patients and 410 events were included in the final analysis. Celiac disease was higher among patients with IBS compared to control subjects, odd ratio, 0.28, 95% CI, 0.14-0.54, I2 for heterogeneity, 78%, P <0.001, and the P-value for overall effect, 0.0002. The results did not change after addressing the heterogeneity, odd ratio, 0.31, 95% CI, 0.22-0.43, I2 for heterogeneity, 33%, P-value, 0.17, and the P-value for overall effect <0.0001. Celiac disease was higher among patients with irritable bowel syndrome compared to their counterparts without IBS and it should be thought of among patients with irritable bowel syndrome, especially in refractory cases. Further studies investigating the management of celiac/IBS overlap are recommended.