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Abstract : The purpose of this study was to use systematic review techniques to look at the relationship between IBS and OCD. We conducted a thorough search of PubMed, SCOPUS, Web of Science, and Science Direct to find pertinent literature. Rayyan QRCI was utilized during the entire process. We included six studies with a total of 970 patients, and 351 (36.2%) were males. Five studies investigated the prevalence of OCD in 340 IBS patients and was found to be 107 (31.5%). Only one study a 10 (47.6%) of IBS in 21 OCD patients. There is a substantial correlation between OCD prevalence and factors like males, younger age groups, single people, and OCD history in close family members of IBS patients. Certain psychological traits and neuroendocrine markers, particularly plasma cortisol and neuropeptide Y, were found to be significantly correlated in IBS patients; in diarrhea-predominant IBS, a correlation between plasma cortisol and serotonin was discovered. IBS patients have a high OCD prevalence, and there is a substantial correlation between OCD and the study's IBS criteria. Consequently, to treat this patient group, gastroenterologists, psychiatrists, and psychologists sought assistance; treatments ought to be carried out collaboratively. To validate the current findings, it is also advised that additional prospective studies look into the relationship between IBS and other psychiatric disorders.