Abstract : Bone tissue is a nanocomposite consisting of an organic and inorganic matrix in which the collagen component and the mineral phase are organized into complex and porous structures. Hydroxyapatite (HA) is the most widely used ceramic biomaterial because it mimics the mineral composition of vertebrate bone. The osteoinductive property can be provided by combining HA with Mg ions. The research design was a systematic review that followed the PRISMA guidelines. This study searched for articles related to scaffolds containing chitosan and magnesium-doped hydroxyapatite, bone tissue regeneration from international databases including PubMed, Web of Science (Clarivate Analytics) and Scopus, and the Cochrane Library and Embase. To find more relevant articles, Google Scholar was also manually searched as well as the reference lists of articles included in the systematic review. The initial search of the reviewed databases resulted in 179 articles that were potentially relevant to the presented review. In this study, the total number of eligible articles retrieved was 96. 81 titles, abstracts, and full texts remained for further screening after removing duplicate records. Of these, 74 did not meet the inclusion criteria and were therefore excluded. Finally, 7 articles were selected for qualitative synthesis. The osteogenic induction property can be provided by combining HA with Mg ions. These studies may provide further insight into the ability to select and customize chitosan- and magnesium-doped hydroxyapatite-based composites for hard tissue engineering applications with bioactive properties.