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Abstract : Cathepsins are the sarcoplasmic proteins which originates from the lysosomes, also known as the lysosomal protease. They have a significant role in the intracellular homeostasis like in the energy metabolism, immune response, intracellular protein dehydration and coagulation. Through this study we aim determine the association between Cathepsin D (CATHD) activity and the parameters which leads to cardiovascular diseases. Multiple parameters which are linked with the heart diseases were examined in the study. The following factors included, total cholesterol (TC), Lactate dehydrogenase (LDH), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Creatine kinase (CK), Triglyceride (TG), Very low density lipoprotein (vLDL), alanine aminotransferase (ALT), arylesterase and cathepsin D (CATHD). A positive correlation between the TGs and atherosclerosis was observed. In addition to it, atherosclerosis was found to be linked with elevated levels of, Total cholesterol, LDL and VLDL. While in case of cardiac diseases, elevated levels of ALT, CK, CATHD and LDH were seen.in the healthy individuals the levels of CATHD were more in females as compared to males, and more in nonsmokers as compared to smokers.