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Abstract : Chronic kidney diseases is associated with disorders of structure and functioning of thyroid gland. Metabolism and hormonal levels may vary in patients having chronic renal failure (CRF). The objective of the study is to analyse the biochemical abnormalities of thyroid function tests in CRF and to correlate its severity and alterations of thyroid indices. Blood samples were analysed from patients (N=152) for serum triiodothyronine (TT3), serum thyroxine (TT4), serum free triiodothyronine (FT3) serum free thyroxin (FT4), thyroid stimulating hormone (TSH). Blood urea estimation was done using diacetyl monoxime (DAM) method and serum creatinine estimation by Modified Kinetic Jaffe method. Clinical examination and history was performed considering thyroid and renal diseases. Mean age of patients was 53.93 ± 9.91 years of which 115 (75.66%) were males and 37 (24.34%) were females. The mean value of TT3 in CRF stage 3, 4, 5 were 118.38±16.66, 111.26±23.13, 85.35±28.77 ng/mL respectively (p= < 0.00). The mean value of FT3 in CRF stage 3, 4, 5 were 2.84±0.43, 2.41±0.58, 2.07±0.66 pg/mL respectively (p=<0.01). The mean value of TT4 in CRF stage 3, 4, 5 were 1.22±0.17, 1.05±0.21, 0.96±0.27 respectively (p= < 0.001). The mean value of FT4 in CRF stage 3, 4, 5 were 1.19±0.00, 1.04±0.24, 0.98±0.24 pg/dL respectively (p= <0.001). TT3, TT4 and FT3 were found to decrease progressively as the stage of CRF increased. Thyroid hormone abnormalities could be a risk factor for cardiovascular disease and kidney disease progression.