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Abstract : Emphysema is associated with high incidence of morbidity and mortality in india. The imbalance between oxidative stress and antioxidants play a major role in the Emphysema pathogenesis. Aim of this study is to estimate serum levels of Malondialdehyde (MDA) as a biomarker of lipid peroxidation and non enzymatic antioxidant vitamin E in Emphysema patients and healthy controls. A total number of 80 subjects comprising of 40 healthy controls and 40 Emphysema cases were studied. Serum malondialdehyde estimated by Kei Satoh Method and Serum vitamin E was measured by Baker and Frank method. Serum MDA was significantly increased in Emphysema patients when compared to controls where as serum level of vitamin E significantly decreased in Emphysema patients when compared to controls. Oxidative stress is increased in Emphysema patients which seems to be associated with active smoking habit and also due to systemic inflammation. The decrease in level of antioxidant in Emphysema patients appears to be consequence of increased oxidative stress and its excess consumption. By advising rich antioxidant diet or additional supplementation of antioxidants may prevent the further oxidative damage in emphysema patients.