About the Journal

Download [This article belongs to Volume - 64, Issue - 05]

Abstract : Energy drinks are cold caffeinated beverages commonly used by adolescents and young adults for increasing physical strength and mental alertness. The global market of EDs has grown dramatically, while the evidence and concern about the potential health risks are also increasing. This study explores the possible effect of two different energy drinks consumption on oxidative stress and neuroinflammation. Fifty adult male Sprague Dawley rats, weighing 120±5g divided into five groups, ten rats in each. Control group: healthy rats received distilled water only. RB-L and RB-H groups received Red Bull 5ml, 15ml/kg/day respectively, while ST-L and ST-H received Sting 5ml, 15ml/kg/day respectively for seven weeks. Our results concerning the effect of EDs on the oxidative stress biomarkers disclosed a significant decrease in SOD, GPX, CAT, and HO-1 in serum and brain tissue homogenate. Additionally, results showed a statistically significant reduction in Nrf-2 relative expression in all EDs-administrated groups. Stimulant neurotransmitters showed a significant increase in dopamine, noradrenaline, and acetylcholine in serum and brain tissue homogenate, which were consistent with findings of histopathological examination that showed severe degenerative changes and pyknosis of neural cells on the cerebral cortex and subiculum of the hippocampus, indicating the toxic effect of energy drinks on neurons of the brain. Both Sting and Red Bull consumption induced oxidative damage and neuroinflammation. Consumption of high dose of Sting showed the most dramatic effect.