Abstract : The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapid worldwide expansion. So far, there is no efficacious therapy for its treatment. Consequently, it is peremptory to identify certain clinical features & laboratory findings for monitoring the disease progression and early diagnosis of patients. To investigate and correlate the variations of the demographic, clinical and laboratory markers based on the severity of COVID-19 and their role in tracing disease progression. This observational analysis included 5016 patients of either gender, aged ≥ 18 years with mild, moderate and severe COVID-19. Data regarding age, gender, medical history, clinical and laboratory data was recovered from medical records of these patients. The retrieved study variables related clinical features & laboratory details like N/L ratio, complete blood count, renal function test, coagulation profile, blood sugars, serum electrolytes etc. were evaluated. The study population showed a male predominance (i.e., 63%) and 68.2% of the COVID population were of mild severity. The main two presenting symptoms were fever (69.3) and cough (36.9%). A significant difference (p<0.05) in the distribution of age, gender and outcome over COVID severity was noted. Also, significant differences (p < 0.001) were noted in many demographic, clinical, and serological parameters between all possible pairs of COVID severity. The COVID-19 severity is associated with specific clinical & deranged laboratory profile. Hence keeping a track of these clinical features & laboratory markers might allow early identification and disease progression prediction.