Abstract : The most common form of lupus is known as systemic lupus erythematosus (SLE). Organs are severely damaged and inflamed due to the immune system's mistaken targeting of healthy tissue in SLE, an autoimmune illness. The cardiovascular system, the brain, the lungs, the skin and the articular cartilage may all be affected. Although there is now no treatment that can reverse the effects of lupus, it may be managed with dietary and pharmaceutical interventions. People with SLE may have many different symptoms, such as fatigue, skin rashes, fevers, and joint pain or swelling. Flares, or periods of increased disease activity, affect some individuals with SLE, while others have remissions. However, SLE flares may occur more often in other persons. In addition to photosensitivity, other symptoms may include mouth ulcers, arthritis, lung, heart, and kidney problems, seizures, psychosis, and blood cell and immunological abnormalities. Therefore, the purpose of this research is to identify and quantify sex hormones in women with SLE, as well as to investigate the links between sex hormones and various forms of arthritis. fifty Iraqi SLE patients were studied between September 2021 and February 2022 in the Rheumatology clinic of the Baghdad Teaching Hospital/Medical City Complex. This research collected blood samples from individuals with SLE to examine complete blood count (CBC), sex hormone, and other factors, and the results show that people with SLE are not all the same. in SLE compared to controls in the frequency distribution of Estrogen, FSH, testosterone, and cortisol.