Polycystic ovary syndrome (PCOS), also called Stein-Leventhal syndrome, is a heterogenous endocrine disorder that affects approximately 4–8% of women of reproductive age. Study the effect of Cressa Cretica leaves extract on induced polycystic ovarian syndrome in rat model, evaluate the effect of Cressa Cretica leaves extract on biochemical markers (adiponectin and serum blood glucose) and hormones (FSH, LH, testosterone and estrogen) and compare the effect of Cressacretica leaves extract with that of metformin. Method: Female rats were administrated with 0.4 mL of oral letrozole (5.3mg/kg) daily for 21 days, followed by a dose of Metformin (500mg/kg) for first group, High dose Cressacretica (400mg/kg) for second group, low dose Cressacretica (300mg/kg) for third group and Combination of (200mg/kg) from Cressacretica with (250mg/kg) from metformin for forth group, the treatment received for 30 days. C. cretica treated group show lower level of glucose, testosterone and LH except that for adiponectin, Estradiol and FSH where it was elevated in comparison to induction group. Cressacretica treated groups observed better results in comparison with metformin in improvement of PCOS symptoms in female rats.