Abstract : Musculoskeletal disorders are still experienced in various activities that involve the use of electronic devices, especially in school students. If not controlled properly, it can reduce student achievement. This study aims to determine the factors associated with musculoskeletal Disorders in offline and online learning activities. The research population is all students who take lectures both online and offline. A cross sectional survey was executed among 175 students who were willing to be involved in the research. The instrument used to measure musculoskeletal Disorders uses the Nordic Body Map (NBM). The statistical test used was chi square test. Respondents who experienced musculoskeletal disorders were 94.3%. Most of the respondents aged ≤ 30 years as much as 95.4% with female sex as much as 79.4%. The position when participating in learning was mostly sitting in chairs, both in classroom chairs and at home as much as 76.0% and devices that used more than one device, as much as 92.0%. Average length of learning time per day is more than 4 hours per day. During learning, 58.3% made efforts to stretch the muscles, with 92.0% stretching for ≤ 5 minutes. In the last 3 months, 16.0% used anti-pain drugs. The results showed that stretching activity and time of learning were associated with perceived musculoskeletal disorders, but contrary stretching and duration of learning were not related. Stretching needs during learning activity to reduce musculoskeletal disorders.