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Abstract : Klebsiella pneumoniae infections are challenging to treat because the high prevalence of klebsiella pneumoniae resistance, which restricts the selection of medications for this illness therapy. This research aims to analyze the risk factors and how they relate to the prevalence of carbapenem antibiotic resistance in infections caused by the Klebsiella pneumoniae. This is an analytic observational research with a cross-sectional design and was carried out at H.Adam Malik Hospital, Medan, Indonesia. The frequency distribution of the demographic data was determined using descriptive statistical analysis. After that, an inferential analysis using Chi Square test was carried out to examine the correlation of the data on a categorical scale. If the bivariate test yielded a p value < 0.25, a multivariate logistic regression test would be conducted. With a p value of ≤0.001 (p <0.05), there was a link between a prior hospitalization history and carbapenem resistance. The patient was 14,840 times more likely to develop carbapenem resistance (95% CI: 1,945-113,327) if they had a history of being hospitalized within the previous three months. Among others, the most significant factor influencing Klebsiella pneumoniae resistance is a prior hospitalization history.