Parenting stress has increased during the Covid-19 pandemic. Parents of children with intellectual disabilities experience high parenting stress during the pandemic. Resilience and self-efficacy can be factors that influence parental stress, but there is still limited research looking at the relationship between resilience and self-efficacy with parenting stress of parents with children who have disabilities during the pandemic. The aimed of this study was to determine the relationship between resilience and self-efficacy with the stress of parents who have children with disabilities during the Covid-19 pandemic. This study used a cross-sectional design. This study used consecutive sampling of 156 respondents from parents who have children with intellectual disabilities aged 5-19 years of 4 Special Schools in Yogyakarta. The instruments used in this study included the Parental stress scale (PSS), Connor-Davidson Resilience Scale-25 (CD-RISC-25), the modified Self-efficacy for Parenting Tasks Index (SEPTI), and General Health Questionnaire-12 (GHQ-12) for screening. Bivariate analysis using Spearman test and Independent T-test. Linear regression analysis was used to determine the most dominant factors affecting parenting stress in parents of children with intellectual disabilities. Most parents (51.3%) experienced high parenting stress with low resilience (51.9%) and self-efficacy (55.8%). There is a significant relationship (p < 0.05) between resilience and self-efficacy with parenting stress which is negatively correlated with resilience values (r -0.21) and self-efficacy (-0.242). Resilience is the most dominant factor influencing parenting stress (β: -0.177). Resilience and self-efficacy are factors that influence the parenting stress of children with intellectual disabilities aged 5-19 years during the Covid-19 pandemic.