Adolescence is a significant developmental age in which changes in biological, emotional, cognitive, and social domains occur. A descriptive correlational design was used to guide this study which aims to identify the direction and the strength of relationships between or among variables. The study included a probability simple random sample of 492 students who were selected from six schools (three schools for boys and three schools for girls) out of 56 schools that are located in Al-Nassiriyah City, southern Iraq. Data were collected through a self-report instrument that include sociodemographic characteristics, Child Anxiety and Depression Scales, Emotion Expression Scale, and the Inventory of Parent and Peer Attachment include. The data were analyzed by using SPSS 26 using the descriptive and inferential statistical measures. The study results display all students are not diagnosed positive for panic anxiety. One student only is diagnosed positive for depression. The expressed reluctance and expressed emotions positively predicted students’ proneness to experience anxiety respectively. On the other hand, family’s socioeconomic status and relationship with father negatively predicted students’ proneness to experience anxiety respectively. The expressed emotion and poor awareness could positively predict more students’ proneness to experience depression respectively. On the other hand, relationship with mother and relationship with peer could inversely predict more students’ proneness to experience depression respectively. The researchers recommend that there is a need for the psychiatric nurses to establish health education activities that rest on delineating the expressed reluctance with the goal of minimizing students’ proneness to experience anxiety.