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Abstract : Sexually transmitted infections (STIs) are a major cause of health, social and economic problems in many countries. Nearly 500 million new cases of STIs occur each year worldwide. The increase in poverty was relater with an increase in the number of street children, vagrants, and unemployed. Without adequate assistance, street children are very vulnerable to negative social excesses, including free sex, which could lead to increased prevalence of STIs in street children. Thus, the objective of this study was to determine the prevalence of STIs among street children, homeless, and unemployed in Surakarta and surrounding areas. This analytical observational study was prospectively conducted by interviews, physical examinations and simple laboratory examinations of rapid tests for HIV and Syphilis. The demographic and subject characteristics results showed total 30 subjects involved in this study, which 19 were male and 11 were female. The marital status showed that 12 subjects were married, while 18 others were not. In the STIs status variable, it was found that 25 subjects, did not have an STIs. Besides, it was also found that 2 subjects had dermatophytosis, 1 subject had parasitic infection, and 3 subjects had pyoderma. The STIs risk factors presented heterosexual (20 subjects), bisexual (3 subjects), homosexual (4 subjects), and multiple partner (3 subjects). In conclusion, several factors, which are gender, age, marital status, skin disorders, and STIs risk factors, have a significant impact on the STIs profile in the population of street children and homeless people.