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Abstract : Gallstone diseases (especially choledocholithiasis) are a significant health issue because they have high incidence due to changes in lifestyle, diet pattern, and sedentary lifestyle, increasing health costs. The prevalence of choledocholithiasis comprises 12% of the adult population in the US. Aside from lifestyle changes, choledocholithiasis is also affected by other factors such as age, gender, genetics, factors related to metabolic syndrome, diet, and medicines consumed. The liver function test is the biochemical test of choice for gallstones and bile duct stones patients where increased ALP enzyme level with GGT can help in establishing the diagnosis of blockage of the bile duct. Therefore, this study is conducted to determine the profile of bile duct stone patients who underwent ERCP in Dr. Wahidin Sudirohusodo General Hospital, Makassar. This is an observational descriptive study with a retrospective cohort approach using a purposive sampling method on bile duct stones patients who underwent ERCP. The results revealed that bile duct stones are mostly found in men (61%), 45-59 years old (40.6%), non-obesity (76.3%), prediabetes (42.4%), non-hyperlipidemia (89%), increased level of AST/SGOT (72%), ALT/SGPT (77%), GGT (76.2%), total bilirubin (81.4%), and direct bilirubin (75.4%). Thus, it concludes that the profile of choledocholithiasis patients in Dr. Wahidin Sudirohusodo General Hospital Makassar in November 2021-November 2022 are mostly men, aged 45-59 years old, without obesity, have prediabetic status, hyperlipidemia, and increased level of AST/SGOT, ALT/SGPT, GGT, total bilirubin, and direct bilirubin.