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Abstract : Treponema pallidum causes syphilis, a systemic disease. In developed countries, the prevalence of syphilis is 90%. Early syphilis lesions are papules in sexual contact sites that appear 10-90 days (on average three weeks) after sexual contact. We are reporting a case of primary syphilis in a 21 years old man who was treated with enhance antibiotic therapy doxycycline and benzathine penicillin to reduce a significant syphilis titer after a month after therapy.