Abstract : Schiff bases and metal complexes have brought the attention of the researchers due to its wide application as bioactive and anticancer compounds. To synthesis new Schiff base derived from aldehyde and diamine derivatives and its three metal complexes (Zn, Co, Ni). The white crystalline Schiff base (1E,1'E)-N,N'-(ethane-1,2-diyl)bis(1-(4-chlorophenyl)methanimine) (E4CPMA) was synthesized from the reflux of one moles of ethane,1-2-diamine and 2 moles of 4-chlorobenzaldehyde. Te metal complexes were also prepared by the reaction of the metals salts solution with the solution of the Schiff base, the characterization of the new compounds was carried out via CHN, FTIR, UV-Vis, molar conductivity, magnetic susceptibility, and melting point. The physical properties of the new compounds show different appearance and melting point, and the metal complexes shows diamagnetic for zinc and paramagnetic for cobalt and nickel. The FTIR spectra shows shifting of the OH, and C=N functional groups indicating the coordination of the Schiff base with the metal ions. The UV-Vis spectra show ILCT and d-d transactions in the metal complexes. Novel Schiff base (E4CPMA) and three metal complexes were successfully synthesized, characterization using different chemical and physical techniques were carried out. The new synthesized compounds are promising as bioactive materials and it is recommended to test its bioactivity as a further work.