Abstract :
The Black Soldier Fly (BSF) (Hermetia illucens) is included in the decomposer fly which is not a disease vector. BSF is widely cultivated because it has high nutritional value with a protein content of 44.26% and a fat content of 29.65%. BSF life has the potential as a raw material in the chitosan manufacturing process because it contains the chemical compounds chitin and chitosan. Chitosan is able to accumulate collagen fibers and produce faster wound healing and as an alternative material for bone remodeling. To find out the potential of BSF life as wound healing and bone remodeling. Database obtained from PubMed, Science direct, Google Schooler databases for the last 5 years from 2019-2023. The keyword used in this research is BSF. The study selection process was included in the data meta-analysis using PRISMA-2020. Screening of full text articles was included in a systematic review based on inclusion and exclusion criteria. The search resulted in a total of 18 articles being entered based on the eligibility criteria. The study search categories obtained include BSF characteristics including larvae (maggot), pupae and shells as wound healing and bone remodeling materials, information related to chitosan from BSF, namely the method of making chitosan, characteristics of chitosan test results, the benefits of chitosan in the process of wound healing and bone remodeling. The purity of BSF chitosan is proven through the FTIR, XRD and TGA functional groups which are recognized by FDA (Florida Dental Association). Chitosan is a bioactive material in bone tissue engineering which can be processed in the form of a gel or scaffold. Chitosan improves osteogenic performance so that it can be used as a material for the treatment of bone defects by increasing the expression of Osteporotegerin (OPG), osteocalcin, BMP-2, osteoblasts and decreasing proinflammatory cytokines IL-6, TNF-α, RANKL which have all achieved good therapeutic effects.