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Abstract : Autogenous connective tissue graft (CTG) combined or not with Injectable Platelet-rich Fibrin (I-PRF) is a reliable techniques for peri-implant soft tissue augmentation. Harvesting the graft from the Maxillary Tuberosity allow a reduced harvesting duration and in principle less pain and morbidity. The aim of this study was to compare the palate or the tuberosity as a donor site on oral health-related quality of life (OHRQoL). The sample patients who benefited from CTG from the palate or the tuberosity with dental implants, from 2021 to 2023, were included. OHRQoL was evaluated postoperatively by OHIP-14 questionnaire. The present study was conducted on 33 patients with insufficient volume of peri-implant soft tissue. The sites were randomly assigned into four groups, Palatal CTG group (n = 10), Palatal CTG + I-PRF group (n = 10), Tuberosity CTG group (n = 10), Tuberosity CTG + I-PRF group (n = 10). The self-administered OHIP-14 was handed out to the patient's 3-days, 7-days, 2-weeks, 4-weeks, and 8-weeks post-surgery. The obtained data were statistically analyzed. The results indicated a significant difference among the groups at measurement periods after (3 days, 7 days, 2 weeks, 4 weeks, and 8 weeks), with a significance level smaller than (0.05) in favor of the maxillary tuberosity group. However, no significant difference was found between the groups after 8 weeks (0.543). Within the limitations of this study, preforming the peri-implant augmentation procedure with a CTG harvested from the tuberosity (T-CTG) might be a viable alternative to the palatal site in terms of OHRQoL. The patient-reported outcome measures tended to favor T-CTG.