Abstract :
Many researches about obesity are to use experimental animal model by providing various diets with various types and compositions to obtain models of obese animal. The aim of the study was to induce animal model obesity, with the standard diet, high fat diet and high fat diet modified. This study used 18 white rats of the Wistar strain, divided three groups, and fed for nine weeks. Before feeding, all rats were measured their body weight, abdominal circumference, and body length. We measured body weight every week, while body length and waist circumference were measured every two weeks. After nine weeks of diet, all rats were subjected to injection of Ketamine and examined for metabolic markers. There was a continuous increase in body weight in the three groups of rats. Still, there was no significant difference in weight gain in the three groups of rats (p>0.05). There was a significant increase in body length and abdominal circumference in the standard and rat groups with a modified high-fat diet (p<0.05), the laboratory examination showed that there were no significant differences in blood glucose and creatinine levels in the three groups but there were significant differences in cholesterol, urea levels in the standard and high-fat diet groups (p<0.05). Giving an excellent standard diet, a high-fat diet, and a modified high-fat diet for nine weeks can result in a continuous increase in body weight by providing significantly different anthropometric examination values on body and abdominal length examinations as well as laboratory results that show differences in neutrophil values, cholesterol, and urea in the three sample groups. It is still necessary to do further research on this obese animal model regarding the content of the diet given and the period of the diet.