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Abstract : Hospitals aim to provide accessible healthcare for all. Nurses play a crucial role and require careful workload management to ensure optimal performance. Job crafting can help nurses customize their workload, improve their job satisfaction, and enhance their nursing abilities. This study was conducted to analyze the effect of Job Demands-Resources on Job Crafting among nurses. A cross-sectional study design was employed involving 143 nurses working at RSUD Labuang Baji in Makassar, South Sulawesi. Total Sampling was used to get the sample. Data was analyzed using Partial Least Square (PLS) multivariate analysis. The results showed that at RSUD Labuang Baji in Makassar, Job Demands had a positive and significant impact on Burnout and Motivation, and a negative and significant impact on Work Engagement. Job Demands also had a positive and significant impact on Job Crafting through Burnout and Motivation, but not through Work Engagement. Job Resources had a positive and significant impact on Burnout and Motivation, but not a significant impact on Work Engagement. Job Resources also had a positive and significant impact on Job Crafting only through Motivation but not through Burnout and Work Engagement. Burnout and Motivation had a positive and significant impact on Job Crafting, while Work Engagement did not have a significant impact. Management was expected to balance job demands and resources to improve nurses' performance and to enhance their job satisfaction through job crafting.